Actively Recruiting
Early Versus Late Adjunctive Vasopressin in Septic Shock
Led by The Cleveland Clinic · Updated on 2026-03-12
300
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of the CASPER-Pilot study is to develop clinical decision support (CDS) technology within Epic to randomize patients with septic shock to early versus standard of care vasopressin initiation. The primary aim of this study will be to test the hypothesis that CDS technology can be utilized to create two distinct cohorts of patients reflecting different times of vasopressin initiation based on norepinephrine dose requirements. Secondarily, this study will evaluate the proportion of patients whose norepinephrine dose at the time of vasopressin initiation is within the specified range for the intervention arm they were randomized to. Other outcomes of evaluation will include adherence to the developed CDS technology and comparison of clinical outcomes between the two treatment arms.
CONDITIONS
Official Title
Early Versus Late Adjunctive Vasopressin in Septic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 18 Years
- Diagnosis of Septic Shock
- Admitted to Cleveland Clinic Main Campus Medical ICU
- Receiving continuous infusion of norepinephrine at a dose > 5 mcg/min at time of enrollment
You will not qualify if you...
- Receiving any vasoactive agent other than norepinephrine at time of enrollment
- Vasopressin started by provider before norepinephrine dose reached 10 mcg/min (before alert)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44095
Actively Recruiting
Research Team
G
Gretchen L. Sacha, PharmD
CONTACT
A
Abhijit Duggal, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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