Actively Recruiting
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
Led by University of Aarhus · Updated on 2025-11-18
250
Participants Needed
2
Research Sites
133 weeks
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838. The aim is to collect early neuromonitoring data to identify key predictors of successful wake-up.
CONDITIONS
Official Title
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Out-of-hospital cardiac arrest of presumed cardiac cause
- Sustained return of spontaneous circulation for more than 20 minutes
- Unconsciousness (Glasgow Coma Scale less than 9) after sustained return of spontaneous circulation at randomization
You will not qualify if you...
- Suspected pregnancy in females of childbearing potential without a negative pregnancy test
- Known bleeding disorders (except medically induced coagulopathy)
- Suspected or confirmed acute intracranial bleeding
- Suspected or confirmed acute stroke
- Unwitnessed asystole
- Known limitations in therapy or Do Not Resuscitate order
- Diseases making survival beyond 180 days unlikely
- Pre-arrest functional status of CPC 3 or 4
- More than 3 hours from return of spontaneous circulation to screening
- Systolic blood pressure below 80 mm Hg despite treatment (unless recovering)
- Use of intra-aortic balloon pump, axial flow device, or ECMO (unless removed during inclusion window)
- Body temperature below 30°C on admission
- Known allergy to dexamethasone or olanzapine
- Ongoing treatment with olanzapine or dexamethasone within 48 hours
- Known back or hip conditions preventing positioning with backrest from 0 to 45 degrees
- Known or suspected Long QT Syndrome
- Active fungal disease (localized skin lesions allowed)
- Estimated body weight less than 45 kg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Department of Intensive Care Medicine
Aarhus N, Denmark, DK-8200
Actively Recruiting
2
Department of Cardiology, The Heart Centre, Rigshospitalet
Copenhagen, Denmark, DK-2100
Actively Recruiting
Research Team
C
Christopher Torp Lohse, MD
CONTACT
A
Anders Grejs, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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