Predicting Early Wake-up Success After Out-of-Hospital Cardiac Arrest An Observational Study Using Neuromonitoring in Danish Hospitals

What this Trial Is About

Researchers are investigating early predictors of wake-up success after out-of-hospital cardiac arrest in a prospective observational substudy WAKE-OHCA of the larger DANOHCA trial. This study focuses on understanding how different neuromonitoring techniques relate to patient outcomes and sedation length in post-resuscitation care. The goal is to identify key patient and neurological factors that influence early and late wake-up, improving decision-making and care strategies for unconscious patients after cardiac arrest. Participants undergo various neuromonitoring tests including automated pupillometry, transcranial doppler ultrasound, optic nerve sheath diameter ultrasound, and continuous EEG with reactivity testing. These measurements are taken at multiple time points from enrollment up to 72 hours in comatose patients to assess neurological status and cerebral blood flow. The study collects data on sedation length, patient variables, and outcomes to analyze predictors of wake-up success and neurological recovery. During the study, researchers collect baseline medical and cardiac arrest data from medical records and registries. Neuromonitoring data is gathered repeatedly within the first 72 hours after enrollment. The primary outcome is the number of patients who successfully wake up early or later according to sedation protocols. Secondary outcomes include mortality, length of ICU and hospital stay, days alive outside the hospital, and neurological function up to six months. Participant safety is monitored throughout, and treatments remain standard care without influence from neuromonitoring results.

Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest