Efficacy of a Multi-level Intervention to Promote Adherence to WCRF/AICR Dietary Guidelines for Cancer Prevention

What this Trial Is About

Researchers are evaluating a multi-level intervention designed to help adults improve their diet according to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines to reduce cancer risk. This study will enroll 472 adults from the community, including index participants and their household members, who currently have low adherence to dietary guidelines focused on increasing fruits, vegetables, and whole grains while reducing processed foods, red and processed meat, and sugary drinks. The study aims to test whether the "Eatwell" intervention leads to better dietary adherence and improved inflammation markers compared to traditional nutrition education. Participants will be randomly assigned to one of two groups. The Eatwell group will receive an 18-month program including 12 workshop sessions focused on healthy grocery shopping, eating at home to benefit from healthier defaults, and handling temptations when eating out. Household members will join four of these sessions to support the index participant. The comparison group will receive traditional nutrition education with the same number and schedule of sessions but without the additional motivation and self-regulation content, and household members in this group will not participate in the intervention. During the study, participants will attend scheduled workshops and complete assessments at baseline, 6 months, and 18 months, including dietary adherence scoring and biomarker measurements related to inflammation through blood draws at partnered commercial laboratories. Researchers will measure changes in dietary patterns and inflammation markers, track adherence using standardized scoring, and evaluate how household support influences outcomes. The study includes ongoing monitoring and the total participation is expected to last 18 months.

Eatwell Clinical Trial (R01)