Actively Recruiting

Phase Not Applicable
Age: 25Years - 45Years
All Genders
ID07365033

Effectiveness of Eccentric Training With Blood Flow Restriction Therapy Versus Resistance Training in Patients With Lateral Epicondylitis

Led by Nimra Rafiq · Updated on 2026-02-05

40

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of two exercise methods for treating chronic lateral epicondylitis, a condition affecting the elbow. This randomized controlled trial compares eccentric training combined with blood flow restriction therapy (ECC+BFR) to heavy slow resistance (HSR) training. The study will include 40 participants aged 25 to 45 years with chronic unilateral lateral epicondylitis lasting more than 12 months, recruited from two hospitals. Participants will be randomly assigned to one of two groups. The interventional group will perform eccentric wrist extensor exercises with blood flow restriction using a pneumatic cuff inflated to 50-60% limb occlusion pressure. These exercises are done at 20-30% of one-repetition maximum (1-RM) with a specific repetition pattern, three times weekly for 8 weeks. The control group will perform heavy slow resistance training at 70-85% of 1-RM, involving slow concentric and eccentric wrist exercises, matched in frequency and duration to the interventional group. During the study, participants will be assessed at the start, 4 weeks, and 8 weeks for pain intensity using the Numeric Pain Rating Scale, functional performance specific to the patient, muscle strength, and muscle size increase. The study uses careful randomization and blinding of outcome assessors to reduce bias. Ethical standards will be followed, with informed consent and privacy protections. The total study duration is 8 weeks of supervised exercise sessions with ongoing safety monitoring.

CONDITIONS

Brief Title

Eccentric Exercise With Blood Flow Restriction vs Resistance Training for Lateral Epicondylitis

Who Can Participate

Age: 25Years - 45Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 25 to 45 years
  • Both male and female participants
  • Clinically diagnosed unilateral lateral epicondylitis confirmed by positive Cozen's and Mills' tests
  • Symptoms lasting more than 12 months indicating chronic lateral epicondylitis
  • Unilateral symptoms only
Not Eligible

You will not qualify if you...

  • Previous surgery or injection therapy for lateral epicondylitis within the past 6 months
  • Coexisting conditions such as rheumatoid arthritis, cervical radiculopathy, or significant tendon tears
  • Contraindications to blood flow restriction including deep vein thrombosis, vascular disease, uncontrolled hypertension, or clotting disorders
  • Use of anticoagulants or long-term pain medications
  • Pregnancy
  • Psychological illness or condition

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 8 weeks

Participants receive supervised exercise sessions either combining eccentric wrist extensor exercises with blood flow restriction therapy or heavy slow resistance training for lateral epicondylitis.

3 visits per week, totaling 24 supervised sessions

Follow-up

Duration - Up to 8 weeks from treatment start

Participants have assessments of pain intensity and functional performance at 4 and 8 weeks after starting treatment to monitor progress and outcomes.

Assessments at baseline, 4 weeks, and 8 weeks

Trial Site Locations

Total: 1 location

1

University of Lahore Teaching Hospital, Lahore

Lahore, Punjab Province, Pakistan, 54000

Actively Recruiting

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Research Team

N

Nimra Rafiq, MS MSK

M

Montiha Azeem, MSPTN

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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