Actively Recruiting
Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-24
700
Participants Needed
1
Research Sites
185 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Staphylococcus aureus is the most frequent cause of both healthcare-associated and community-acquired bloodstream infections worldwide. Infective endocarditis (IE) has been detected in 5-17% of cases and is a determinant of poor prognosis. The investigators developed a score (the VIRSTA score) based on patients' characteristics to rule out IE with high confidence (negative predictive value (NPV) above 99%) in patients with SAB. This score, with a cut-off of 3 has been externally validated by two international studies which have also established its high NPV. The 2023 European society of cardiology (ESC) guidelines state that echocardiography should be considered in all patients with Staphylococcus aureus bacteremia (SAB) using risk scores (including VIRSTA score) to guide the use or not of echocardiography. While recommended, the investigators think that VIRSTA score must be evaluated in terms of patients' outcome.
CONDITIONS
Official Title
Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Volunteers over 18 years of age
- Hospitalized with at least one blood culture positive for Staphylococcus aureus
- Negative control blood culture performed 48 hours after the first Staphylococcus aureus blood culture collection
- VIRSTA score less than 3
You will not qualify if you...
- Catheter colonization without SAB, defined as positive blood cultures only from vascular access device specimen
- Referred to hospital for management of infective endocarditis
- Contraindication to transthoracic echocardiography (TTE)
- Echocardiography already performed before inclusion for current SAB
- Pregnancy
- Under guardianship or trusteeship
- Absence of written informed consent
- No social security affiliation
- Already involved in another interventional clinical trial requiring echocardiography
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bichat Claude Bernard Hospital
Paris, France, 75018
Actively Recruiting
Research Team
X
Xavier Duval
CONTACT
S
Sarah Tubiana
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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