ECMM Candida Registry - CandiReg: Observational Study on Invasive Candida Infections and Antifungal Resistance

What this Trial Is About

Researchers are conducting the European Confederation of Medical Mycology (ECMM) Candida Registry, called CandiReg, to improve understanding of invasive Candida infections. The study aims to gather comprehensive data on the global occurrence, clinical progression, molecular features, and antifungal resistance of invasive Candida infections. It also seeks to identify patient risk groups, assess mortality and costs related to these infections, and support future research and outbreak responses. The study uses a web-based registry to collect information on invasive Candida infections worldwide. It documents diagnostic methods, treatment approaches including first-line and salvage therapies, adherence to guidelines, and their effects on patient survival. The registry also collects Candida isolates for molecular analysis and resistance gene evaluation to track trends over time and support guideline development. Participants diagnosed with invasive Candida infections contribute clinical data and isolates, while matched controls from the same hospitals are included for comparison. Researchers monitor incidence, mortality, molecular characteristics, susceptibility testing, and resistance development up to 100 weeks after diagnosis. Treatment efficacy and the clinical course of disease are also assessed. The study provides long-term observation without administering experimental treatments, with participation lasting as long as data collection continues.

ECMM Candida Registry - CandiReg