Actively Recruiting
The ECMOCYP (cytochromes P450 Activity) Study
Led by University Hospital, Geneva · Updated on 2024-10-28
46
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Geneva
Lead Sponsor
J
Jean Terrier
Collaborating Sponsor
AI-Summary
What this Trial Is About
Prospective open label observational study including patients requiring a tMCS (VA-ECMO or Impella® CP) or in in cardiogenic shock according to the SCAI (Society for Cardiovascular Angiography and Interventions) ESC (European Society of Cardiology) definition 41,42 and not requiring or not eligible to tMCS (ECMO, Impella®, intra-aortic balloon pump) (control group).
CONDITIONS
Official Title
The ECMOCYP (cytochromes P450 Activity) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients with refractory cardiogenic shock requiring temporary mechanical circulatory support (VA-ECMO or Impella42 CP)
- Male and female patients in cardiogenic shock per SCAI and ESC definitions not requiring or not eligible for temporary mechanical circulatory support (control group)
- Age over 18 years old
- Able to understand French
- Able to give consent or consent provided by therapeutic representative or relatives if sedated and intubated; patient consent sought at second blood sample after tMCS removal
You will not qualify if you...
- Patients with refractory ARDS requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO)
- Unable to receive the Geneva cocktail by enteral route
- Severe or terminal renal impairment (GFR < 30 ml/min by Cockroft-Gault)
- Severe chronic hepatic insufficiency (CHILD B-C)
- Sensitivity to any drug in the Geneva cocktail
- Use of drugs strongly altering CYP activity (strong inhibitors or inducers)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Of Geneva
Geneva, Switzerland, 1205
Actively Recruiting
Research Team
J
Jean Terrier, Dr
CONTACT
A
Anastasia Zaslavskaya, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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