Actively Recruiting
ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL
Led by Brigham and Women's Hospital · Updated on 2025-02-10
120
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial effective comfort in 90% of patients (post test-dose ED90) via the epidural (DPE or EPL) technique in women undergoing labor induction or augmentation; the investigators hypothesize that the investigators will be able to determine the post test-dose ED90 of bupivacaine for each technique with adequate precision to inform the optimal doses to study in a subsequent randomized trial comparing the analgesic effects of DPE vs. EPL. The investigators also hypothesize that the post test-dose ED90 of bupivacaine is lower with a DPE technique than with a conventional epidural technique.
CONDITIONS
Official Title
ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant woman in labor with no major health problems
- Single baby in head-down position at term (37 to 42 weeks gestation)
- Cervical dilation of 5 centimeters or less
- Desire to receive epidural labor pain relief
- Pain rating of 5 or higher on a 0-10 scale at time of epidural request
You will not qualify if you...
- Presence or history of significant diseases or pregnancy complications such as preeclampsia or gestational diabetes
- Any reason that prevents safe epidural use, like low platelet count or use of blood thinners
- Known allergy or unusual reaction to amide local anesthetics
- Expected problems with the baby, including fetal anomalies or growth issues like IUGR, low or excessive amniotic fluid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
L
Lawrence Tsen, MD
CONTACT
A
Ayumi Maeda, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here