Actively Recruiting
EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder
Led by Wave Neuroscience · Updated on 2025-03-24
110
Participants Needed
2
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.
CONDITIONS
Official Title
EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to consent to participate in the study via signed Informed Consent
- Age 22 - 65 years
- Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS)
- PTSD symptoms persisting for at least 6 months prior to the Screening Visit
- Veterans Administration PCL-5 cut point score of 31 or above
- Positive identification as either a Veteran or First Responder (e.g., emergency medical service provider, firefighter, or other emergency response personnel)
You will not qualify if you...
- Uncontrolled medical, psychological or neurological condition
- Pregnant, or female unwilling to use effective birth control during the course of the trial
- Metal objects in the head
- Past exposure to metal fragments, permanent piercings, or other possible metal sources in the head and neck
- Current participation in any interventional research protocol
- History of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)
- History of stroke, intracranial lesion, or increased intracranial pressure
- History of epilepsy or seizure
- Family history of epilepsy or seizure in a first-degree relative
- Elevated risk of suicide or violence to others
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Wright State University
Dayton, Ohio, United States, 45435
Actively Recruiting
2
D2 Human Performance Center
Pickerington, Ohio, United States, 45435
Actively Recruiting
Research Team
M
Matthew Sherwood, PhD
CONTACT
W
Walter Mysiw, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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