Inclusion Criteria:

• Female and male healthy individuals (ASA I: assessed according to the American Society of Anesthesiologists Physical Status Classification System a non-acute or chronic disease), non-pregnant, non-smokers, non-drug-users, and presenting no or minimal alcohol use.
• Age: 18 to 35 years
• Capacity to give consent
• Written consent after detailed information.

Exclusion criteria:

• Individuals who do not meet all inclusion criteria
• Previous brain surgery
• History of epileptic seizures
• History of psychiatric or neurological disease
• Physical status other than American Society of Anesthesiologists physical status I, e.g., presence of severe internal or systemic disease
• Chronic intake of medication or drugs (Alcohol, Marihuana, Cocaine, Opioids, Benzodiazepine, etc.)
• Impaired hearing or presence of deafness
• Absence of fluency in the German language
• Known disposition to malignant hyperthermia
• Previous diagnosis of hepatic porphyria
• Body mass index greater than 30 kg/m2
• Gastrointestinal disorders with a disposition for gastroesophageal regurgitation
• Known or suspected difficult airway
• Known hypersensitivity to propofol or any propofol injectable emulsion components (i.e., eggs, eggs products, soybeans, or soy products)
• Atopy/severe allergies/asthma
• Cardiological abnormalities: torsades de pointes, prolonged QT interval, QT changes present since birth.
• Contraindications to MRI (e.g., pacemakers, artificial heart valves, cardioseal, aneurysm clips, implanted magnetic metal parts (screws, plates from surgery), cochlear implants, metal splitters/grenade splinters, acupuncture needle, insulin pump, piercings that cannot be removed, etc)
• Pregnancy
• Subjects with claustrophobia

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety