Actively Recruiting

Phase Not Applicable
Age: 15Years - 30Years
All Genders
Healthy Volunteers
NCT06045897

EEG Microstates Across At-Risk Mental States

Led by Centre Hospitalier St Anne · Updated on 2023-09-21

126

Participants Needed

1

Research Sites

165 weeks

Total Duration

On this page

Sponsors

C

Centre Hospitalier St Anne

Lead Sponsor

A

Assistance Publique - Hôpitaux de Paris

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). The main questions it aims to answer are: * are EEG microstate anomalies associated with diagnosis, clinical and functional prognosis, both in resting conditions and during sleep ? * are EEG microstates anomalies associated with differences in sensorimotor integration, prosodic and conversational, interoceptive, and narrative self ? * an ancillary study will be to see whether in healthy controls EEG microstate properties vary under light hypnosis conditions. Participants will: * undergo deep phenotyping based on psychopathology and neuropsychological assessments * undergo a high-resolution EEG (64 electrodes) with a resting period and a sensorimotor task; and healthy controls will have a light hypnosis period. * undergo a recording of the characteristics of their voice (tone, prosody) * undergo a one-night polysomnography * undergo MRI and biological sampling for multi-omic analyses * undergo a virtual reality experience

CONDITIONS

Official Title

EEG Microstates Across At-Risk Mental States

Who Can Participate

Age: 15Years - 30Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 15 and 30 years
  • Meet CAARMS criteria for stage Ia or Ib mental states at risk
  • Meet DSM-5 criteria for first episode psychosis
  • Meet DSM-5 criteria for depressive disorder
  • Meet DSM-5 criteria for autism spectrum disorder
  • Healthy controls recruited from general population
Not Eligible

You will not qualify if you...

  • Suicidal risk
  • Severe or unstable somatic or neurological disorders
  • Epilepsy
  • Head trauma
  • IQ below 70
  • Family history of psychosis for healthy controls
  • Bipolar disorder
  • Obsessive-compulsive disorder
  • Substance use disorder except cannabis up to 5 joints/day

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences

Paris, France, 75014

Actively Recruiting

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Research Team

A

Anton Iftimovici, MD, PhD

CONTACT

V

Valeria Lucarini, MD, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

6

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