Actively Recruiting
EEG Microstates Across At-Risk Mental States
Led by Centre Hospitalier St Anne · Updated on 2023-09-21
126
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier St Anne
Lead Sponsor
A
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). The main questions it aims to answer are: * are EEG microstate anomalies associated with diagnosis, clinical and functional prognosis, both in resting conditions and during sleep ? * are EEG microstates anomalies associated with differences in sensorimotor integration, prosodic and conversational, interoceptive, and narrative self ? * an ancillary study will be to see whether in healthy controls EEG microstate properties vary under light hypnosis conditions. Participants will: * undergo deep phenotyping based on psychopathology and neuropsychological assessments * undergo a high-resolution EEG (64 electrodes) with a resting period and a sensorimotor task; and healthy controls will have a light hypnosis period. * undergo a recording of the characteristics of their voice (tone, prosody) * undergo a one-night polysomnography * undergo MRI and biological sampling for multi-omic analyses * undergo a virtual reality experience
CONDITIONS
Official Title
EEG Microstates Across At-Risk Mental States
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 15 and 30 years
- Meet CAARMS criteria for stage Ia or Ib mental states at risk
- Meet DSM-5 criteria for first episode psychosis
- Meet DSM-5 criteria for depressive disorder
- Meet DSM-5 criteria for autism spectrum disorder
- Healthy controls recruited from general population
You will not qualify if you...
- Suicidal risk
- Severe or unstable somatic or neurological disorders
- Epilepsy
- Head trauma
- IQ below 70
- Family history of psychosis for healthy controls
- Bipolar disorder
- Obsessive-compulsive disorder
- Substance use disorder except cannabis up to 5 joints/day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences
Paris, France, 75014
Actively Recruiting
Research Team
A
Anton Iftimovici, MD, PhD
CONTACT
V
Valeria Lucarini, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
6
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