Actively Recruiting
EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
Led by Poitiers University Hospital · Updated on 2026-01-23
120
Participants Needed
8
Research Sites
218 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment. Participants will be randomized into antiarrhythmic drugs alone or atrial fibrillation ablation + antiarrhythmic drugs.
CONDITIONS
Official Title
EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 60 to 80 years
- Persistent atrial fibrillation
- Patients with an indication for cardiac rhythm control
- Montreal Cognitive Assessment score between 18 and 25 points indicating mild cognitive impairment
- Free subject, not under temporary or permanent guardianship and not subject to subordination
- Subject understands and accepts the study requirements
- Patient covered by French national health insurance or through a third party
- Subject has given written consent after clear and complete information
You will not qualify if you...
- Unable to perform neuropsychological evaluation due to communication issues or language barriers
- History of clinical stroke
- Presence of carotid bruit or history of severe carotid stenosis
- History or suspicion of neurodegenerative disease, bipolar disorder, schizophrenia, severe depression, or amyloidosis
- Previous atrial fibrillation ablation
- Currently undergoing flutter or atrial tachycardia ablation (not atrial fibrillation ablation)
- Contraindications to atrial fibrillation ablation (e.g., intracardiac thrombus, severe pulmonary hypertension, mechanical mitral valve prosthesis, anticoagulation contraindication)
- Contraindications to antiarrhythmic drugs or implantable cardiac monitor
- Very advanced persistent atrial fibrillation (over 3 years duration or large left atrial size on echocardiography)
- Life expectancy less than 24 months at enrollment
- Unable to provide consent
- Persons under reinforced protection, such as minors, detainees, adults under legal protection, or emergency patients
- Pregnant or breastfeeding women or women of childbearing potential not using effective contraception
AI-Screening
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Trial Site Locations
Total: 8 locations
1
CHU Angers
Angers, France
Actively Recruiting
2
University Hospital
Brest, France
Actively Recruiting
3
University Hospital
Caen, France
Actively Recruiting
4
University Hospital
Dijon, France
Actively Recruiting
5
CHU Grenoble
Grenoble, France
Actively Recruiting
6
La Timone
Marseille, France
Actively Recruiting
7
University Hospital
Poitiers, France
Actively Recruiting
8
Centre Cardiologique du Nord
Saint-Denis, France
Not Yet Recruiting
Research Team
R
Rodrigue Garcia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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