Testing Accelerated Deep Transcranial Magnetic Stimulation and Cognitive Training to Improve Memory in Older Adults with Mild Cognitive Problems

What this Trial Is About

Researchers are evaluating whether an accelerated deep Transcranial Magnetic Stimulation dTMS combined with cognitive training can improve cognitive abilities in older adults aged 55 to 85 who have Subjective Cognitive Decline SCD or Mild Cognitive Impairment MCI. This study aims to determine the safety and tolerability of this accelerated dTMS protocol and gather early information about its effects on memory and other cognitive functions. It is a double-blind, randomized, sham-controlled trial conducted at a single site by the Rotman Research Institute at Baycrest. Participants will be randomly assigned to receive either active dTMS using the Brainsway H7-Coil or a sham stimulation using the H1-Coil helmet. The dTMS is administered 6 to 8 times daily for 2 to 5 consecutive days, followed by 6 weeks of online cognitive remediation for all participants. This accelerated intermittent theta burst stimulation a-iTBS targets the anterior cingulate cortex ACC to explore its potential to enhance cognitive training effects. During the study, participants will be closely monitored for attendance, adverse events, and reasons for withdrawal. Cognitive abilities, including memory and executive function, will be assessed with computerized neuropsychological tests before and after treatment. Additional evaluations include anxiety and depression scales, brain activity through EEG and MEG, and MRI scans to measure brain connectivity. The entire participation lasts at least 9 weeks, with safety and cognitive changes tracked throughout the study period.

Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems