Actively Recruiting
Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems
Led by Rotman Research Institute at Baycrest · Updated on 2025-10-28
30
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol in combination with cognitive training can improve cognitive abilities in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI). The study will look at whether it is safe and tolerable to use accelerated dTMS to enhance the benefits of cognitive training in older adults, and will also gather early information on the effects of accelerated dTMS on memory and other cognitive abilities.
CONDITIONS
Official Title
Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 55 to 85 years of age on the day of randomization
- Male or post-menopausal female
- Diagnosis of mild cognitive impairment (MCI) based on Montreal Cognitive Assessment score less than 26 or clinical neuropsychological assessment, OR subjective memory concerns with a first-degree relative diagnosed with Alzheimer's disease
- Score of 24 or higher on the Mini Mental State Examination (MMSE)
- Willing to provide informed consent
- Able to follow the treatment schedule
- Stable on medications for 2 months and no expected medication changes during the study
- Satisfactory safety screening questionnaire for TMS
You will not qualify if you...
- Metal plate in the head (e.g., ear implant, implanted brain stimulators, aneurysm clips); dental devices and non-magnetic implants are allowed
- Known or history of increased brain pressure
- Cardiac pacemaker
- Implanted medication pump
- Central venous line
- History of psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia
- History of substance abuse in the last 6 months
- History of stroke or brain lesions
- Personal or family history of epilepsy
- Pregnant or breastfeeding women
- History of abnormal brain MRI
- Untreated hypo- or hyper-thyroidism
- Unstable medical conditions
- Other known contraindications to TMS
- Unstable doses of psychotropic medications (antidepressants, antipsychotics, mood stabilizers, memory enhancing drugs)
- Regular use of benzodiazepines or hypnotics within 2 weeks of randomization
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Rotman Research Institute at Baycrest
Toronto, Ontario, Canada, M6A 2E1
Actively Recruiting
Research Team
A
Amanda Chao, MPH
CONTACT
L
Linda Mah, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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