Actively Recruiting
Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF
Led by Huazhong University of Science and Technology · Updated on 2026-03-10
771
Participants Needed
1
Research Sites
356 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).
CONDITIONS
Official Title
Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Married women aged 25-40
- Repeated implantation failure for unknown reasons with 2 or more embryo transfers of good-quality embryos without clinical pregnancy
- Availability of transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB)
- Estrogen and progesterone replacement therapy with endometrial thickness ≥7mm on the day of endometrial transformation
You will not qualify if you...
- Preparing for preimplantation genetic diagnosis (PGD)
- Recipients of egg donors
- Chromosomal abnormalities in one or both partners (excluding chromosome polymorphism)
- Implantation failure due to known embryonic factors
- Uterine lesions affecting implantation such as uterine malformation, fibroids >4cm, submucosal fibroids, adenomyosis, uterine tuberculosis, or intrauterine adhesions
- Repeated spontaneous abortion with 2 or more fetal losses before 28 weeks gestation
- Other endocrine diseases with poor hormone control in the last 3 months (thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease)
- Diagnosed autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome
- Untreated hydrosalpinx
- Body mass index (BMI) less than 18 or greater than 25 kg/m2
- History of needle sickness
- Previous participation in this study or acupuncture treatment within the past 3 months
- Any condition deemed inappropriate for participation by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tongji Hospital,Tongji medical college,HUST
Wuhan, Hubei, China, 430030
Actively Recruiting
Research Team
C
Cuihong Zheng, professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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