Study of Acupuncture Effects on IVF Pregnancy Success in Women with Repeated Implantation Failure Aged 25 to 40

What This Trial Is About

Researchers are evaluating the effect of acupuncture on pregnancy outcomes in women with recurrent implantation failure RIF undergoing in vitro fertilization IVF. This randomized, placebo-controlled multicenter trial takes place in five centers in China and aims to compare acupuncture combined with IVF, sham acupuncture combined with IVF, and IVF alone. The study focuses on women aged 25 to 40 who have experienced repeated implantation failure for unknown reasons despite multiple embryo transfers. Participants are randomly assigned to one of three groups acupuncture plus IVF, sham acupuncture plus IVF, or IVF only. Acupuncture and sham acupuncture treatments are performed three times a week for 30 minutes each session, beginning on the 5th day of menstruation before the transfer cycle and ending within 24 hours after embryo transfer. The control group receives only the IVF procedure without acupuncture. During the study, researchers will monitor clinical pregnancy rates as the primary outcome within one year. Secondary outcomes include ongoing pregnancy rates, live birth rates, biochemical indexes, questionnaire scores before and after acupuncture treatment, and the rate of positive -HCG within one year. Participants will be assessed through these measures to evaluate the impact of acupuncture on IVF pregnancy outcomes.

Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF