Actively Recruiting
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
Led by University Hospital, Lille · Updated on 2025-05-13
60
Participants Needed
1
Research Sites
294 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.
CONDITIONS
Official Title
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cannabis consumer group: Cannabis use more than 100 times in lifetime, last use less than 7 days ago, and more than 10 times in the past month
- Positive urine test for delta-9-THC
- Cannabis use disorder diagnosed by CAST
- Healthy group: Negative urine test for cannabis
- No regular cannabis use for more than 6 months lifetime
- No cannabis use in the 6 months before the study
You will not qualify if you...
- Use disorders of other substances such as alcohol, cocaine, opioids, or synthetic drugs
- Alcohol intake over 30g per day on average or alcohol abuse the week before visit
- Currently under medical treatment
- Diagnosed neurological disorders
- Diagnosis of psychotic disorders as per DSM-5
- Chronic progressive disease or in remission
- Body mass index over 30 kg/m2 (obesity)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Lille
Lille, France, 59000
Actively Recruiting
Research Team
O
Olivier Cottencin, MD,PhD
CONTACT
F
Francois-xavier Gamelin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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