Study on How Acute Low Oxygen Levels Affect Kidney Blood Flow in Healthy Adults and Adults with Diabetes or Diabetic Kidney Disease

What this Trial Is About

Researchers are studying the effects of acute hypoxia on kidney blood flow and function in healthy volunteers, patients with type 2 diabetes, and those with diabetic kidney disease. Diabetes is a growing health concern worldwide, often leading to kidney problems that current screening methods may detect only in later stages. This research aims to explore early changes in kidney function related to low oxygen levels, which play a role in diabetic kidney disease progression. Participants undergo two exposure periods a 3-hour normal oxygen breathing phase and a 2-hour hypoxia phase at oxygen levels simulating 3000 meters altitude. Kidney function is assessed using diagnostic agents measuring effective renal plasma flow and glomerular filtration rate. The study also collects data on mitochondrial metabolites, blood pressure, heart rate, oxygen saturation, and symptoms during the sessions. Throughout the study, participants will be monitored with blood tests, questionnaires, and imaging scans to evaluate kidney function and overall response to hypoxia. The main outcomes measured over 5 hours include kidney filtration rates and plasma flow. Secondary measures such as blood pressure and oxygen saturation are also recorded. The study is expected to last several hours per participant, with follow-up assessments extending up to 8 days to capture metabolic changes.

Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease