Actively Recruiting
The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise
Led by Maastricht University Medical Center · Updated on 2025-09-24
27
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.
CONDITIONS
Official Title
The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18-50 years of age
- Trained cyclist or triathlete with VO2peak > 55 ml/kg/min for males and > 48 ml/kg/min for females
- Healthy based on medical history and investigator's judgment
- Provided written informed consent
You will not qualify if you...
- Use of medications that affect study outcomes or ketone supplement action (e.g., gastric acid suppressors, statins, corticosteroids)
- Smoking
- Diagnosed acute or chronic medical conditions that could affect outcomes (e.g., diabetes mellitus)
- Diagnosed musculoskeletal disorders
- Following a carbohydrate restrictive diet
- Participating in another study currently
- Blood donation within 2 months before first trial
- Plasma donation within 2 weeks before first trial
- Males with VO2peak below 55 ml/kg/min
- Females with VO2peak below 48 ml/kg/min
- Pregnancy in females
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maastricht University Medical Center+
Maastricht, Limburg, Netherlands, 6229ER
Actively Recruiting
Research Team
L
Luc van Loon, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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