Actively Recruiting
The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-03-14
150
Participants Needed
1
Research Sites
99 weeks
Total Duration
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AI-Summary
What this Trial Is About
The prevention of intraoperative allogenetic blood transfusion has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery. Data from previous studies suggest that the clinical efficacy of acute normovolemic hemodilution (ANH) has always been controversial, and intraoperative fluid administration strategy is an important confounding factor. The HEAL trial will assess whether ANH will reduce the volume of intraoperative allogeneic red blood cell transfusion when applying goal-directed fluid therapy in patients undergoing bone tumor surgery.
CONDITIONS
Official Title
The Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Scheduled for elective bone tumor resection surgery
- Preoperative hemoglobin level of at least 11 g/dL
You will not qualify if you...
- Use of a tourniquet during surgery
- Undergoing palliative or minimally invasive surgery
- Body mass index (BMI) less than 18.5 or greater than 30 kg/m2
- International normalized ratio (INR) greater than 1.5 or platelet count less than 100 x 10^9/L
- Cardiopulmonary insufficiency
- Liver or kidney dysfunction
- Active infection
- Allergy to succinyl gelatin
- Pregnancy
- Declined participation or blood transfusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University anesthesiology department
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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