Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest

What this Trial Is About

Researchers are evaluating the effects of adding glycerol to electrolyte beverages on fluid balance in healthy men and women who are well hydrated and at rest. This study follows earlier research suggesting that glycerol combined with sodium can improve fluid retention and balance. The study aims to test if fluid balance is maintained and greater than placebo after drinking carbohydrate-electrolyte beverages with varying glycerol content. The study has two parts where participants consume different carbohydrate-electrolyte drinks with and without glycerol or a placebo beverage. Each beverage is given in three doses of 9.3 oz (276 ml) over 35 minutes, followed by a rest period before measuring outcomes. Participants may take part in both parts of the study with dosing days spaced 2 to 15 days apart. Beverages are matched for color and flavor to maintain consistency. Participants will undergo multiple assessments including body weight and percent change in body mass before and after beverage consumption at several time points up to 150 minutes post-dose. Additional tests include measuring fluid retention, urine output, blood sodium and glucose levels, plasma volume changes, blood pressure, heart rate, and subjective symptoms like headache or lightheadedness. Menstrual status is also recorded at screening. The study involves careful monitoring and data collection to understand fluid balance effects over time.

Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest