Actively Recruiting
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
Led by PepsiCo Global R&D · Updated on 2025-02-11
95
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical interpretation is that addition of glycerol enables a reduction in sodium concentration compared with a 0% glycerol drink. In this follow-up study, the investigators hypothesize that 1) fluid balance will be sustained (greater than or not different from baseline) and significantly greater than placebo for 120 min after drinking the test no/low/moderate carbohydrate beverages and 2) fluid balance will not differ between the carbohydrate-electrolyte beverages, but both will be greater than placebo.
CONDITIONS
Official Title
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- If female, not pregnant (based on self-report)
- Age between 18 and 50 years, inclusive
- At least recreationally active (light to moderate exercise at least 3 days per week for 30 minutes each session)
- Non-smoker or quit smoking for at least 6 months
- Not taking medications that may interfere with the study (e.g., diuretics)
- No health conditions interfering with the study, such as cardiovascular, renal, or metabolic diseases
- No allergy to adhesives (e.g., medical tape)
- No allergy to kiwi-strawberry flavoring
- Willing to avoid alcohol for 24 hours before visits
- Willing to fast overnight (about 8-12 hours)
- Willing to avoid vigorous exercise for 24 hours before visits (only light physical activity allowed)
- Willing to eat the same food the day before each laboratory visit
- Able to speak, read, and write English
- Provide written consent to participate
You will not qualify if you...
- Participated in any clinical trial within the past 30 days
- Participated in any PepsiCo trial within the past 6 months
- Has a condition or taking medication that interferes with informed consent, study compliance, results interpretation, or safety
- Employed by or has immediate family employed by a company competing with Gatorade products
- If unsure about competitor status, must inform the investigator before consenting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
PepsiCo R&D, Gatorade Sports Science Institute
Valhalla, New York, United States, 10595
Actively Recruiting
Research Team
L
Lindsay Baker, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
7
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