What is the study of furosemide and albumin aiming to find out for critically ill patients with fluid overload?

This study is assessing whether adding albumin to furosemide improves urine output and kidney function in critically ill adults with fluid overload. Researchers want to see if the combination enhances the diuretic effect compared to furosemide alone. The trial is led by Dr. Jose J Zaragoza and focuses on important kidney and fluid balance measures.

Who may be eligible for this clinical trial involving fluid overload treatment?

Adults aged 18 to 100 years who are critically ill and admitted to the intensive care unit with low urine output for at least 6 hours may be eligible. People receiving dialysis or end-of-life care, pregnant or breastfeeding women, and those in other clinical trials may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this clinical trial for fluid overload?

Study-related care, including the study drug or procedure and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 100Years

All Genders

ID07417969

Comparing Furosemide Alone Versus Furosemide Plus Albumin for Fluid Overload in Critically Ill Adults Impact on Urine Output and Kidney Function

Led by Jose J Zaragoza, MD MSc · Updated on 2026-06-16

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

This research evaluates how well furosemide alone compares to furosemide combined with albumin in critically ill adults who have fluid overload. The study aims to find out if adding albumin improves urine output and kidney function markers compared to using furosemide by itself. Key measurements include urine output two hours after treatment, kidney blood flow indicators, and various biochemical tests. Participants are randomly assigned to receive either furosemide at 1 mg per kg of body weight intravenously over 30 minutes with a placebo, or the same dose of furosemide together with 50 grams of 25% albumin infused over 30 minutes. The study uses bedside ultrasound to assess fluid overload signs and monitors blood pressure, electrolytes, and kidney filtration rates during the trial. During the study, participants undergo urine output measurement at two hours and blood tests to track changes in kidney function and electrolyte levels up to 24 hours after treatment. Ultrasound evaluations assess vein size and congestion at baseline and after two hours. Researchers monitor safety and response to treatment while collecting data on urine volume and kidney health markers to understand the impact of adding albumin to furosemide therapy.

CONDITIONS

Brief Title

"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"

Who Can Participate

Age: 18Years - 100Years

All Genders

Eligibility Criteria

You may qualify if you...

Adults 18 years and older
Critically ill patients admitted to intensive care units
Presence of low urine output defined as less than 0.5 mL per kg per hour for at least 6 hours

You will not qualify if you...

Patient or legal representative refuses participation
Patients receiving palliative or end-of-life care
Acute or chronic kidney failure requiring renal replacement therapy at enrollment
Chronic dependence on dialysis
Participation in another interventional clinical trial
Pregnant or breastfeeding women

Research Team

Alina Elizabeth Arechiga Casas, MD

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