Actively Recruiting
Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
Led by University of Colorado, Denver · Updated on 2024-10-08
300
Participants Needed
1
Research Sites
756 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to lung infections and respiratory failure. Subjects are asked to be in this research study because they are thought to have a lung infection and may also have respiratory failure. Alcohol, tobacco, and drug use have been linked to lung infections, respiratory failure, and even death, but the reasons for this aren't known. People who use unhealthy amounts of alcohol, tobacco, and or drugs may be more at risk for lung infections, and for severe complications due to lung infection. Subject participation is important whether or not you use alcohol and or drugs.
CONDITIONS
Official Title
Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult medical ICU patients admitted to the University of Colorado Hospital for a primary respiratory problem, expected to require ICU care for 48 hours or more
- Adult medical ICU patients with respiratory failure requiring endotracheal intubation and mechanical ventilation
- Adult medical and other ICU patients with respiratory failure not related to lung condition, requiring endotracheal intubation and mechanical ventilation
- Adult ICU patients previously admitted for a primary respiratory problem requiring ICU care for 48 hours or more
You will not qualify if you...
- Patients expected to require ICU care less than 48 hours
- Patients admitted to ICU but not in ICU status (housed for space issues)
- Patients unlikely to survive 48 hours
- Patients on comfort care or hospice measures
- Patients younger than 18 or older than 90 years
- Prisoners
- ICU attending declines enrollment
- Pregnant patients
- Patients with significant anemia (Hgb <8% or Hct <24%) or active bleeding
- For bronchoscopy: patients with FiO2 >80% or PEEP >10 cm H2O
- Patients with platelets less than 30,000 (chronic)
- Patients expected to undergo spontaneous breathing trial or extubation within 4 hours
- Patients with endotracheal tube smaller than 7.5 F
- Patients currently dangerously agitated
- Outpatients only exclusions: residency greater than 40 miles from UCH clinics
- Non-English or non-Spanish speakers
- Inability to perform study procedures or pulmonary function testing
- Diagnosis of chronic pulmonary disease (e.g., COPD)
- Diagnosis of chronic neurodegenerative disease or severe dementia
- History of anoxic or traumatic brain injury
- Prior ICU hospitalization at a non-UCH facility
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
E
Ellen L Burnham, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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