Studying How Alcohol and Drug Use Affects Immune Response in Critically Ill Adults With Lung Failure

What this Trial Is About

Researchers are studying how alcohol and drug use affects people hospitalized with lung infections or respiratory failure. Respiratory failure is a serious condition where the lungs cannot properly oxygenate the blood or remove carbon dioxide. The study focuses on adults admitted to the intensive care unit ICU with respiratory problems to understand the impact of alcohol, tobacco, and drug use on illness severity and outcomes. Participants include adult ICU patients with respiratory issues, some of whom require mechanical ventilation. Researchers will collect various biological samples like blood, breath condensate, urine, and hair during the first 10 days of hospital stay. A subset will also undergo bronchoalveolar lavage. The study follows patients during their hospital stay, expected to last about 17 days, with follow-ups at 3 and 6 months to assess alcohol use disorders and respiratory failure causes. During the study, participants will be monitored in the ICU, with samples collected to characterize alcohol and drug use. Researchers will observe the prevalence and causes of respiratory failure and how these relate to substance use. The study includes safety checks and tracks changes over time through hospital and follow-up visits, aiming to improve understanding of risks and complications in critically ill patients.

Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure