Actively Recruiting
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
Led by Copenhagen University Hospital, Hvidovre · Updated on 2025-03-18
74
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance. The study involves adult participants suffering from dermatological or rheumatological illness, who are planning to start treatment with monoclonal antibodies targeting interleukin 17 as a part of the treatment of these diseases. The primary outcome of this study will be changes in airway hyperresponsiveness to methacholine challenge reported as response-dose-ratio before and after initiation of anti-IL17 treatment regardless of presence of respiratory disease. Furthermore, the potential effect of anti-IL-17 on airway resistance will be assessed using conventional spirometry for measuring changes in FEV1 and Airwave oscillometry. A reduced degree of airway hyperreactivity and airway resistance after initiating ani-IL-17 could indicate effectiveness of anti-IL-17 in asthma patients which would have to be examined further in a population of asthma patients.
CONDITIONS
Official Title
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients planning to start treatment with anti-IL-17 antibodies
You will not qualify if you...
- Current pregnancy
- FEV1 less than 1.5L or less than 60% of predicted value
- Previous anaphylactic shock or severe allergic reaction to medicine
- Uncontrolled hypertension
- Myocardial infarction or stroke within the last 3 months
- Known aortic aneurysm
- Recent eye surgery or risk of elevated intracranial pressure
- Treatment with systemic corticosteroids within 6 weeks
AI-Screening
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Trial Site Locations
Total: 1 location
1
Respiratory Research Unit Hvidovre Department of Respiratory Medicine, Copenhagen University Hospital
Hvidovre, Capital Region, Denmark, 2650
Actively Recruiting
Research Team
J
Jonas A Baekdal, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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