Actively Recruiting
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
Led by Osijek University Hospital · Updated on 2026-02-06
56
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery. Patients undergoing surgical resection of lung cancer often require one-lung ventilation during anaesthesia. This results in alveolar hypoxia accompanied by upregulated expression of inflammatory markers. Apneic oxygenation of the non-ventiladed lung may influence inflammatory processes and oxygenation during surgery. The aim of this study is to evaluate whether apneic oxygenation affects inflammatory markers in lung tissue and postoperative recovery in patients undergoing lung cancer surgery. The study is conducted at a single center and includes adult patients scheduled for elective lung cancer surgery. Data will be collected durig the perioperative period. The results of this study may contribute to improved anaesthetic management and patient outcomes during thoracic surgery.
CONDITIONS
Official Title
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Scheduled for surgical resection of a single lung segment for lung cancer
- Provided written informed consent
You will not qualify if you...
- Younger than 18 years old
- Receiving chronic corticosteroid or other immunomodulatory treatments
- Severe pulmonary diseases including COPD GOLD stage 3-4, severe asthma GINA step 4, or severe interstitial lung disease with FVC < 50% predicted or DLCO < 40% predicted
- Surgical procedure expected to last less than 2 hours
- Intraoperative hemodynamic instability with mean arterial pressure < 60 mmHg for over 30 minutes despite volume resuscitation or high-dose vasopressors
- New intraoperative cardiac arrhythmias
- Significant intraoperative blood loss requiring transfusion of more than two units of red blood cells
- Intraoperative ventilatory instability including severe hypoxemia, hypercapnia with acidosis, or inability to achieve adequate ventilation
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Center Osijek
Osijek, Croatia, 31000
Actively Recruiting
Research Team
H
Hrvoje Vinković, MD, PhD candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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