Impact of Apneic Oxygenation on Lung Tissue Inflammation and Recovery During Lung Cancer Surgery

What this Trial Is About

This research aims to evaluate the impact of apneic oxygenation of the non-ventilated lung on local and systemic inflammation during lung cancer surgery. It focuses on patients undergoing surgical resection for lung cancer, where one-lung ventilation causes alveolar hypoxia and increases inflammatory markers. The study compares inflammatory responses and postoperative recovery between patients receiving apneic oxygenation and those receiving standard ventilation during surgery. Participants will be randomly assigned to either receive apneic oxygenation of the non-ventilated lung or standard ventilation during lung resection. Anesthesia is induced and maintained using specific medications, with lung separation achieved via a double-lumen endotracheal tube. Tissue samples from the lung will be collected during surgery for detailed immunohistochemical analysis of inflammatory markers HIF-1 and IL-6. Postoperative care includes monitoring in the intensive care unit, pain management, and assessment of lung function and complications. Throughout the study, patients will have blood tests before and after surgery, continuous vital sign monitoring in the intensive care unit, and daily pulmonary function assessments during their hospital stay. Researchers will measure inflammatory marker expression in lung tissue during surgery, changes in blood cell counts and blood gases, incidence of postoperative complications, and overall recovery. The study may improve anesthesia management and outcomes for patients undergoing thoracic surgery.

Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.