Actively Recruiting
Effect of Apneic Oxygenation of the Non-ventilated Lung on Inflammatory Markers HIF-1 and IL-6 During Lung Cancer Surgery
Led by Osijek University Hospital · Updated on 2026-02-06
56
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effect of apneic oxygenation of the non-ventilated lung on inflammatory responses and oxygen levels during lung cancer surgery. The study focuses on adult patients undergoing surgical lung resection for lung cancer. Researchers want to see if delivering oxygen to the non-ventilated lung affects inflammatory markers in lung tissue and impacts postoperative recovery, potentially improving anesthesia management during thoracic surgery. The study includes 56 patients randomly assigned to two groups: one receiving apneic oxygenation of the non-ventilated lung and the other receiving standard ventilation during surgery. Patients will be prepared with anesthesia, including propofol, sufentanil, and rocuronium, and lung tissue samples will be collected during surgery for detailed analysis of inflammatory markers HIF-1 and IL-6. Oxygen will be delivered via a catheter in the apneic oxygenation group, while the control group will not receive this intervention. Participants will be closely monitored before, during, and after surgery. Blood tests, vital signs, and pain scores will be recorded, along with lung function and oxygen therapy needs during hospitalization. Researchers will track postoperative complications and overall recovery. The main outcomes measured are the expression of inflammatory markers in lung tissue during surgery, along with changes in blood counts and oxygen levels up to 24 hours after surgery. The study period includes intensive care monitoring and hospital stay until recovery.
CONDITIONS
Brief Title
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Patients scheduled to undergo surgical resection of a single lung segment for lung cancer
- Written informed consent provided
You will not qualify if you...
- Age younger than 18 years
- Chronic corticosteroid therapy and/or other immunomodulatory treatments
- Severe pulmonary diseases including COPD GOLD stage 3-4
- Severe asthma classified as GINA step 4
- Severe interstitial lung disease with FVC < 50% predicted or DLCO < 40% predicted or extensive fibrosis on CT
- Surgical procedure expected to last less than 2 hours
- Intraoperative hemodynamic instability with mean arterial pressure < 60 mmHg for over 30 minutes despite treatment
- Requirement for high-dose vasopressors (norepinephrine > 0.2 bcg/kg/min)
- New-onset intraoperative cardiac arrhythmias
- Significant intraoperative blood loss requiring transfusion of more than two units of red blood cells
- Intraoperative ventilatory instability including severe hypoxemia, hypercapnia, or inability to achieve adequate ventilation
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for preoperative evaluation and baseline data collection
Duration - Duration of the surgical procedure
Participants undergo lung cancer surgery with either apneic oxygenation applied to the non-ventilated lung or standard ventilation. Tissue samples are collected during surgery for immunohistochemical analysis.
1 visit (in-person) on the day of surgery
Duration - Up to 24 hours post-surgery
Participants are monitored in the intensive care unit for the first 24 hours after surgery, including continuous vital sign monitoring and routine laboratory tests. Postoperative pain management is provided and pain intensity is assessed.
Continuous monitoring during ICU stay with laboratory tests 6 and 24 hours after surgery
Duration - Until hospital discharge
Participants remain hospitalized for daily assessment of pulmonary function and oxygen therapy. Postoperative complications and overall recovery are documented until discharge.
Daily assessments during hospital stay
Trial Site Locations
Total: 1 location
1
University Hospital Center Osijek
Osijek, Croatia, 31000
Actively Recruiting
Research Team
H
Hrvoje Vinković, MD, PhD candidate
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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