Actively Recruiting
The Effect of Aspirin on Recurrent Acute Pancreatitis
Led by Air Force Military Medical University, China · Updated on 2023-12-29
23
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recurrent acute pancreatitis (RAP) was defined as two or more occurrences of acute pancreatitis, which was associated with higher percentages of morbidities and mortalities, lower patients' life quality and increased health-care costs. Current interventions, including cholecystectomy and abstain from drinking were reported to be effective methods for preventing the recurrences of biliary and alcoholic etiologies, respectively. However, there were no effective preventions for other etiologies, such as idiopathic etiologies. Non-steroid anti-inflammatory drugs (NSAIDs), including indomethacin, diclofenac and aspirin could inhibiting the inflammatory cascade of pancreatitis. In this study, we aimed at exploring the effects of 100mg aspirin on reducing the occurrences of recurrent acute pancreatitis.
CONDITIONS
Official Title
The Effect of Aspirin on Recurrent Acute Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with recurrent acute pancreatitis
You will not qualify if you...
- Less than 2 episodes of acute pancreatitis in the past year
- Pancreatitis caused by endoscopic retrograde cholangiopancreatography, surgery, or other invasive treatments
- Previous allergy to non-steroid anti-inflammatory drugs (NSAIDs)
- Regularly taking aspirin or other NSAIDs more than 3 doses per week
- Contraindications for NSAIDs including active peptic ulcer disease or gastrointestinal bleeding within 3 months, previous peptic ulcer, significant liver or kidney disease, low platelet count, or high INR
- Presence of biliary stones
- Recent or planned endoscopic sphincterotomy, pancreatic stent placement, cholecystectomy, or pancreatic surgery within 2 years
- Serum triglycerides over 5.65 mmol/L without regular lipid-lowering treatment
- Primary hyperparathyroidism not well treated or planned surgery within 2 years
- Previous heavy alcohol use without quitting or with withdrawal symptoms
- Pregnant or breastfeeding
- Inability to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Air Force Military Medical University, China
Xi'an, Shaanxi, China, 710032
Actively Recruiting
Research Team
Y
Yanglin Pan, MD
CONTACT
X
Xiaoyu Kang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here