Actively Recruiting
The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
Led by Larissa University Hospital · Updated on 2025-07-18
30
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing. Participants will : 1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed. 2. baseline characteristics will me monitored throughout the interventions 3. Esophageal pressure and minute ventilation will be monitored.
CONDITIONS
Official Title
The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- No symptoms or signs of respiratory failure (oxygen saturation above 95% on room air)
You will not qualify if you...
- Pregnancy
- Oxygen saturation below 94% on room air
- Neuromuscular disease
- Contraindications to esophageal pressure monitoring such as uncontrolled bleeding, esophageal disease, nasal injury, or allergy to local lidocaine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Larissa, Department of Pulmonary Medicine
Larissa, Greece, 41222
Actively Recruiting
Research Team
I
Ioannis Dr. Pantazopoulos, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here