Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis.
Chrysi Koliaki, Julia Szendroedi, Kirti Kaul...
https://pubmed.ncbi.nlm.nih.gov/25955209Actively Recruiting
Age: 20Years - 70Years
All Genders
Healthy Volunteers
ID01477957
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism in Obesity Grades 2 and 3
Led by German Diabetes Center · Updated on 2025-01-10
450
Participants Needed
1
Research Sites
847 weeks
Total Duration
On this page
Sponsors
G
German Diabetes Center
Lead Sponsor
D
Dep.of General-, Visceral- and Pediatric Surgery, HHU, Duesseldorf, Germany
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how bariatric surgery affects insulin sensitivity and energy metabolism in adults with obesity grades 2 and 3. The study aims to understand how insulin resistance relates to fat buildup in muscles and the liver, which can impair insulin function and glucose use. It also explores how liver inflammation links to fatty liver disease in these patients. The research focuses on uncovering the mechanisms behind insulin resistance and liver disease associated with obesity and diabetes. Participants will undergo bariatric surgery, including procedures such as biliopancreatic diversion, gastric banding, or gastric sleeve resection. These surgeries aim to reduce body weight significantly and may lead to rapid improvements in glucose tolerance before weight loss occurs. The study evaluates how these surgical interventions influence energy metabolism and insulin sensitivity over time. During the study, participants' energy metabolism will be monitored for up to five years. Researchers will assess changes in insulin sensitivity, fat storage in muscles and liver, and liver inflammation. Various tests and evaluations will be conducted to measure these outcomes, helping to identify new treatment targets for diabetes and metabolic liver disease. Safety and metabolic changes will be closely followed throughout the study period.
CONDITIONS
Official Title
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
Who Can Participate
Age: 20Years - 70Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Aged 20 years to 70 years
- BMI 20-25 kg/m2 for normal-weight group
- BMI 35-39.9 kg/m2 for obesity grade 2
- BMI greater than 40 kg/m2 for obesity grade 3
You will not qualify if you...
- Acute illness within 2 weeks before examination
- Autoimmune or immune disorders with leukocytes less than 5000/µl
- Kidney problems with creatinine over 1.5 mg/dl
- Heart disease or history of heart attack
- Anemia with hemoglobin less than 12 g/l or recent blood donation within 4 weeks
- Participation in another clinical trial within last 2 weeks
- Use of pharmacological immunotherapy (Cortisol, Antihistamines, ASS)
- Thyroid disorders
- Glitazone therapy
- Pregnancy, lactation, or menstruation
- Smoking, alcohol, or drug abuse
- Psychiatric disorders
- Risk for or diagnosed HIV/AIDS or Hepatitis B/C
- Liver diseases not caused by non-alcoholic steatohepatitis
- Night shift work or irregular sleep patterns
- Poor wound healing or clotting problems
- Allergy to local anesthetics
- Malignant cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Trial Site Locations
Total: 1 location
1
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, Germany, 40225
Actively Recruiting
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Research Team
S
Sabine Kahl, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity.
Sabine Kahl, Klaus Straßburger, Giovanni Pacini...
https://pubmed.ncbi.nlm.nih.gov/39218222Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes.
Leona Kovac, Sofiya Gancheva, Markus Jähnert...
https://pubmed.ncbi.nlm.nih.gov/38977261Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease.
Theresia Sarabhai, Sabine Kahl, Sofiya Gancheva...
https://pubmed.ncbi.nlm.nih.gov/38122893Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease.
Kalliopi Pafili, Sabine Kahl, Lucia Mastrototaro...
https://pubmed.ncbi.nlm.nih.gov/35988689Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.
Maria Apostolopoulou, Ruth Gordillo, Chrysi Koliaki...
https://pubmed.ncbi.nlm.nih.gov/29602794