Actively Recruiting
The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road
Led by Universiti Sains Malaysia · Updated on 2025-12-10
75
Participants Needed
2
Research Sites
10 weeks
Total Duration
On this page
Sponsors
U
Universiti Sains Malaysia
Lead Sponsor
S
Shanghai Jiao Tong University School of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Journeying along the historic Silk Road exposes travelers to dramatic dietary shifts, unfamiliar microbial environments, and the physical stresses of long-distance travel-all known to disrupt gut health and cause gastrointestinal complaints, including traveler's diarrhea and sleep disturbances. Such disruptions may also elevate the risk of acquiring antibiotic-resistant organisms. This randomized, double-blind, placebo-controlled trial evaluated whether probiotic supplementation can help maintain gut microbial balance and support traveler well-being during trips to Silk Road regions. In addition to monitoring changes in gut microbiota composition, the study assessed gastrointestinal symptoms, sleep quality, anxiety levels, overall well-being, gut immune markers, functional profiles of the microbiome, and the presence of antibiotic resistance genes.
CONDITIONS
Official Title
The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Generally healthy adults
- Scheduled to undertake a short-term round trip (less than 7 days) abroad
- Able to complete study procedures
- Willing to take intervention products
You will not qualify if you...
- Use of antibiotics, probiotics, hormones, immunosuppressants, biologics, or JAK inhibitors within 4 weeks prior to study
- Chronic or severe systemic diseases including cardiovascular, hepatic, renal, malignant, or psychiatric disorders
- Uncontrolled parasitic infections
- Long-term use of corticosteroids, growth hormone, vitamin B12, lysine, or inositol
- Major surgery within one month
- Allergy to probiotic components
- Other conditions deemed inappropriate by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shanghai Jiao Tong University School of Medicine
Huangpu, Shanghai Municipality, China, 200001
Actively Recruiting
2
Universiti Sains Malaysia
George Town, Pulau Pinang, Malaysia, 11800
Not Yet Recruiting
Research Team
M
Min Tze Liong, Ph.D.
CONTACT
J
Jie Yuan, M.Sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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