Effect of botulinum toxin A on vasoconstriction and sympathetic neurotransmitters in a murine random pattern skin flap model.
Tai Suk Roh, Bok Ki Jung, Insik Yun...
https://pubmed.ncbi.nlm.nih.gov/27997734/Actively Recruiting
Led by Yonsei University · Updated on 2025-03-17
15
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating how subcutaneous injections of botulinum toxin A affect healing of wounds caused by lower extremity ischemia, a condition where blood flow to the legs is reduced or blocked. This condition often affects elderly patients or those with diabetes, causing chronic wounds or ulcers due to narrowed or blocked blood vessels. The study focuses on patients with wounds on their feet where blood circulation relies mainly on collateral vessels.
CONDITIONS
Effect of Blood Flow by Botulinum Toxin Injection for Severe Peripheral Artery Occlusive Disease
H
Hiisun J, Dr
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Yonsei University
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 14 days
Participants receive a subcutaneous injection of Botulinum toxin A in and around the wound to improve blood flow and promote wound healing.
Visits at baseline, 7 days, and 14 days after injection
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Tai Suk Roh, Bok Ki Jung, Insik Yun...
https://pubmed.ncbi.nlm.nih.gov/27997734/Yonsei University
Lead Sponsor