Actively Recruiting
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
Led by University Hospital, Basel, Switzerland · Updated on 2026-01-23
12
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
CONDITIONS
Official Title
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI between 18.5 and 25 kg/m2
- Able to give informed consent by signing
- Moderate caffeine consumption (1 to 3 cups of coffee per day)
- Increase in energy expenditure of at least 5% in response to mild cold exposure
You will not qualify if you...
- Known allergy or hypersensitivity to caffeine
- Taking medications other than prescription-free painkillers (paracetamol, NSAIDs) or oral contraceptives
- Significant other diseases such as kidney failure, liver problems, heart disease, arrhythmia, high blood pressure, diabetes, or thyroid disorders
- History of depression or anxiety disorders
- Smoker or regular tobacco user
- Habitual excessive alcohol use
- Regularly consuming caffeine-containing energy drinks
- Weight change over 5% in the past 3 months
- Systolic blood pressure over 140 mmHg or diastolic over 95 mmHg
- Resting heart rate over 90 beats per minute
- Sensitivity to cold (e.g., Raynaud syndrome)
- Suspected or known drug or alcohol abuse
- Inability to follow study procedures due to language, psychological, or cognitive issues
- Investigator, their family, employees, or dependents enrolled
- Participation in another study with ionizing radiation in the past 12 months
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Basel, Department of Endocrinology
Basel, Switzerland, 4031
Actively Recruiting
Research Team
M
Matthias Betz, Prof.
CONTACT
J
Jaël Senn, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here