Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity

Led by University Hospital, Basel, Switzerland · Updated on 2026-07-31

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.

CONDITIONS

Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity

Age: 18Years - 40Years

All Genders

Healthy Volunteers

Inclusion Criteria:

Exclusion Criteria:

Known hypersensitivity or allergy to caffeine
Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives
Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia, hypertension, diabetes mellitus, hyper- or hypothyroidism)
History of depressive disorder or anxiety disorder
Smoker / habitual tobacco use
Habitual excessive alcohol use
Regular consumption of caffeine containing energy drinks
Weight change of >5% within 3 months prior to inclusion
Systolic blood pressure >140 mmHg and/or diastolic blood pressure > 95 mmHg.
Resting heart rate >90 bpm
Hypersensitivity to cold (e.g. Raynaud syndrome)
Known or suspected non-compliance, drug or alcohol abuse
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
Enrolment of the investigator, his/her family members, employees, and other dependent persons
Enrolment into another study using ionizing radiation within the previous 12 months.
Pregnancy or lactation

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