Actively Recruiting
Effect of Cannabis on Cigarette Use Behavior
Led by Johns Hopkins University · Updated on 2026-01-16
100
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.
CONDITIONS
Official Title
Effect of Cannabis on Cigarette Use Behavior
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 21 or older
- Daily use of combustible tobacco cigarettes
- Expired carbon monoxide level over 5 ppm and positive urine cotinine test to confirm cigarette use
- Use cannabis at least once per week
- Experience inhaling cannabis
- Positive urine THC test to confirm cannabis use
- Willingness to use effective contraception if of childbearing potential or have partners of childbearing potential
You will not qualify if you...
- Planning to reduce or quit cannabis or tobacco use within the next 30 days
- Substance use disorder other than alcohol, cannabis, or nicotine
- Positive test for illicit drugs other than cannabis and tobacco
- Positive breath alcohol test at study admission
- Current physical or mental illness that may affect safety or study integrity
- Lifetime history or current suicidal behavior or thoughts
- Currently pregnant, breastfeeding, or planning pregnancy within 3 months
- History of significant heart rhythm problems or vasospastic disease
- Participation in another clinical trial or drug study within 30 days before this study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins University Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
L
Lauren Brogdon, MHS
CONTACT
D
Dustin Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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