Study on How Different Doses of Cannabis Affect E-Cigarette Use and Body Responses

What this Trial Is About

Researchers are evaluating how different doses of tetrahydrocannabinol THC affect the motivation, feelings, and physical responses related to electronic cigarette use. The study focuses on adults who use e-cigarettes daily and also consume cannabis. It aims to measure changes in e-cigarette demand, tobacco craving, mood, heart rate, blood pressure, carbon monoxide levels in breath, and cognitive performance. The study uses a double-blind, placebo-controlled, crossover design where participants receive three doses of THC 0, 5, and 30 mg across six visits. Participants are randomly assigned to either smoke or vaporize THC to compare the effects of different administration methods. Each visit also includes use of e-cigarettes with either 0% or 5.0% nicotine to examine combined effects. During the study, participants will complete various assessments at multiple time points, including surveys on nicotine withdrawal and smoking urges, heart rate and blood pressure measurements, and cognitive tests. These evaluations occur from baseline up to six hours after THC or placebo administration. The researchers will closely monitor demand for e-cigarettes, physiological responses, and subjective experiences to understand how THC influences tobacco product use.

Effect of Cannabis on E-Cigarette Use Behavior