Actively Recruiting
The Effect of CBD on Sleep Quality Following Late Evening Exercise
Led by KU Leuven · Updated on 2026-05-06
20
Participants Needed
1
Research Sites
11 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial is a double-blind, placebo-controlled crossover design. In a randomized order, 20 participants undergo one control and two experimental sessions separated by a 1-week wash out period. During the no exercise/rest session, participants' sleep is monitored via polysomnography following a rest day. During the training sessions participants' sleep is monitored following a high intensity interval training (HIIT) in the late evening (finishing 1h prior to bedtime). During these sessions participants receive 2x 200mg CBD or placebo in a randomized order.
CONDITIONS
Official Title
The Effect of CBD on Sleep Quality Following Late Evening Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary written informed consent obtained before screening
- Use of highly effective birth control during the trial and for 4 months after last CBD dose
- Age between 18 and 40 years at consent
- Recreationally active between 2 and 8 hours per week
- Good health confirmed by sport medical screening
- Body fat below 20% for males or 25% for females as measured by DXA scan
- Good sleep efficiency with Pittsburgh Sleep Quality Index score of 4 or less
You will not qualify if you...
- Self-reported sleep disturbances
- Habitual smoking more than once per month
- Any injury or incapability preventing high intensity interval training
- Female who is pregnant, breastfeeding, intends to become pregnant, or is of child-bearing potential without effective contraception
- Participation in another interventional trial with investigational medicinal product or device
- Use of CBD products or cannabinoids within 3 months before trial start
- Use of medications or supplements affecting sleep quality within 3 months before trial start
- Shift workers or extreme morning/evening chronotypes based on Morningness-Eveningness Questionnaire scores
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bakala Athletic Performance Facility
Leuven, Vlaams-Brabant, Belgium, 3001
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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