Actively Recruiting
Effect of Cervical Lymphaticovenous and Lymph Node-to-Vein Anastomosis in Patients With Intracranial Lymphatic Circulation Disorder
Led by Hong Joonpio · Updated on 2026-01-09
114
Participants Needed
1
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a single-center, prospective clinical trial designed to evaluate the therapeutic effects of lymphaticovenular anastomosis (LVA) and lymph node-venous anastomosis (LNVA) in patients with intracranial lymphatic circulation disorders. Following voluntary written informed consent, screening assessments will be performed in accordance with the clinical trial protocol. Eligibility will be determined based on the predefined inclusion and exclusion criteria, and eligible subjects will be enrolled in the study. Enrolled participants will undergo cognitive function assessments at baseline (pre-surgery) and at 1, 3, 6, 9, 12, 18, and 24 months postoperatively for follow-up. Cognitive evaluations will not be additionally performed for research purposes but will be conducted in accordance with the existing clinical care schedule and standard treatment guidelines.
CONDITIONS
Official Title
Effect of Cervical Lymphaticovenous and Lymph Node-to-Vein Anastomosis in Patients With Intracranial Lymphatic Circulation Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 19 years or older diagnosed with intracranial lymphatic circulation disorder by neurological evaluation
- Global Deterioration Scale (GDS) score between 3 and 5 at screening
- Confirmed Alzheimer's disease diagnosis by amyloid PET-CT or cerebrospinal fluid amyloid testing showing amyloid accumulation linked to lymphatic circulation disorder
- Able to provide voluntary written informed consent to participate in the study
You will not qualify if you...
- Unable to complete follow-up evaluations for at least 12 months after surgery
- Diagnosis of vascular dementia
- Presence of structural brain disease other than intracranial lymphatic circulation disorder
- Known allergy or hypersensitivity to indocyanine green (ICG)
- Uncontrolled severe systemic medical conditions such as cardiopulmonary, renal, hepatic, or endocrine disorders
- History of previous neck surgery
- Refusal to participate or failure to provide informed consent
- Considered unsuitable for participation by the principal investigator for any clinical reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Asan Medical Center
Seoul, South Korea
Actively Recruiting
Research Team
J
Jin geon Guen, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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