Study of How Changing Carbohydrate Intake Affects Blood Sugar Control in Adults with Type 1 Diabetes

What this Trial Is About

Researchers are studying the effect of changes in carbohydrate intake on blood glucose control in adults with type 1 diabetes. This study aims to explore whether adjusting dietary patterns can improve glucose levels and understand the related biological mechanisms, including effects on the gut environment, immune function, and metabolism. The study focuses on patients who rely on insulin therapy and have stable treatment plans. Participants are randomly assigned to one of two diet groups a diverse carbohydrate diet where carbohydrates account for 45-55% of total energy with nearly equal parts from refined and whole grainsbeans, or a moderate carbohydrate diet with 45-55% carbohydrates mostly coming from refined grains. Both diets distribute energy intake over three meals daily with specific proportions for breakfast, lunch, and dinner. During the study, participants will be monitored over 14 weeks with measurements including time in range TIR for blood glucose, glucose variability indices, HbA1c, insulin dose changes, and hypoglycemia events. Researchers will also evaluate changes in gut microbiota, metabolomics, and immune markers. Various blood tests and assessments will be conducted from baseline to 2 weeks and 14 weeks to track the impact of the dietary interventions.

Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes