Study of Ciprofol Versus Propofol for Preventing Low Blood Pressure During Surgery in Patients 65 and Older on Renin-Angiotensin System Inhibitors

What this Trial Is About

This research aims to evaluate whether ciprofol, a new intravenous anesthetic, can improve blood pressure stability during surgery in elderly patients who have been using renin-angiotensin system inhibitors long-term. These patients often face increased risk of low blood pressure during surgery, which can lead to serious complications like heart and kidney injury or higher mortality. Ciprofol has shown promise in previous studies for better maintaining blood pressure compared to propofol, but more evidence is needed. The study randomly assigns patients undergoing elective abdominal surgery lasting over two hours to receive either ciprofol or propofol for anesthesia induction and maintenance. Both drugs are given intravenously during surgery. The trial is designed as a triple-blind, randomized controlled trial to compare how each anesthetic affects perioperative blood pressure and related outcomes. Participants will be monitored from the start to the end of surgery for blood pressure levels, use of blood pressure medications, anesthesia success, and any adverse events. Additional measures include heart and brain oxygen levels and recovery times. Postoperative complications will be tracked for up to three months. This thorough monitoring aims to understand the safety and hemodynamic effects of ciprofol in this vulnerable group.

Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors