Actively Recruiting
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-12-30
140
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.
CONDITIONS
Official Title
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective abdominal surgery under general anesthesia
- Duration of surgery exceeding 2 hours
- Patients receiving long-term renin-angiotensin system inhibitor therapy (>3 months prior to surgery)
- Age 65 years
- ASA classification II-III
- Informed consent was obtained from patients or their guardians
You will not qualify if you...
- History of allergy to opioids, propofol, or ciprofol components
- Anticipated difficult airway or difficult mask ventilation
- Body mass index 18 or 35 kg/m
- Severe hepatic dysfunction (total bilirubin 3.0 mg/dL or AST/ALT 2 times the upper limit of normal)
- Severe renal impairment (creatinine clearance 30 mL/min)
- Cardiac diseases including advanced AV block, heart rate <50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or unstable angina on the day of surgery
- Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness
- Abnormal thyroid-stimulating hormone levels or history of thyroid replacement therapy
- Unstable asthma or history of asthma
- Alcohol abuse, drug abuse, chronic opioid dependence, or analgesic use exceeding 3 months
- Lactating or pregnant women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University anesthesiology department
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
M
Min Yan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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