Actively Recruiting
Effect of Colchicine on Coronary Reperfusion in Patients With Acute Coronary Syndrome
Led by Pontificia Universidad Catolica de Chile · Updated on 2025-05-31
50
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
P
Pontificia Universidad Catolica de Chile
Lead Sponsor
F
Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized clinical trial will determine the treatment effect of colchicine (1.5 mg loading dose and 0.5 mg daily thereafter) for 6 weeks on microvascular coronary reperfusion and infarct size in patients with acute coronary syndrome.
CONDITIONS
Official Title
Effect of Colchicine on Coronary Reperfusion in Patients With Acute Coronary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Adults hospitalized for acute coronary syndrome with chest pain and elevated ultrasensitive troponin levels, with or without ECG changes
- Patients planned for coronary angiography and angioplasty during current hospitalization
- Ability and willingness to provide written informed consent
You will not qualify if you...
- ST-segment elevation myocardial infarction requiring emergency angioplasty
- Severe left main coronary artery stenosis
- Advanced heart failure with left ventricular ejection fraction below 35%
- Known intolerance or previous use of colchicine for other conditions
- Severe liver disease (transaminase elevation 3 times above normal)
- Blood dyscrasia with low leukocyte or platelet counts
- Use of CYP3A4 or calcineurin inhibitors
- Active autoimmune disease or chronic anti-inflammatory therapy
- Concomitant infection
- Pregnancy or lactation
- Any disease limiting life expectancy to less than 1 year
- Any medical condition judged by physician to pose significant risk for trial participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Clínico Pontificia Universidad Catolica de Chile
Santiago, Santiago Metropolitan, Chile, 8330024
Actively Recruiting
Research Team
G
Gonzalo Martínez, MD
CONTACT
M
Maria Paz Orellana
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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