Actively Recruiting
The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery
Led by Tomsk Cardiology Research Institute · Updated on 2025-09-09
140
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Development of a new comprehensive method for perioperative prevention of atrial fibrillation paroxysms in cardiac surgery patients at the hospital stage. It is planned to recruit 70 patients who will undergo pericardial fenestration during the operation using the original technique during coronary artery bypass grafting (Patent No. 2647626 C1 Russian Federation), and will be prescribed colchicine (the drug "Colchicum-dispert") in the perioperative period in order to prevent the development of paroxysms of atrial fibrillation in the postoperative period, and 70 cardiac surgery patients operated on using the standard technique (without performing the pericardial fenestration procedure intraoperatively), receiving non-steroidal anti-inflammatory drugs in the postoperative period.
CONDITIONS
Official Title
The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective coronary artery bypass grafting on pump
- Signed informed consent to participate in the study
You will not qualify if you...
- Left ventricular ejection fraction less than or equal to 35%
- Valvular heart disease requiring surgical correction
- Liver failure with liver transaminases elevated 1.5 times or more
- Renal failure with GFR less than 35 mL/min/1.73 m2 (CKD-EPI)
- Permanent, persistent, or paroxysmal atrial fibrillation
- Previously implanted pacemaker
- Hypersensitivity to colchicine
- Neutropenia
- History of alcoholism
- Refusal to sign informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
Tomsk, Russia, 634012
Actively Recruiting
Research Team
M
Mariia L Diakova, PhD
CONTACT
Y
Yuri Y Vechersky, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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