Does a combined intravenous-volatile anesthesia offer advantages compared to an intravenous or volatile anesthesia alone: a systematic review and meta-analysis.
Alexander Wolf, Helene Selpien, Helge Haberl...
https://pubmed.ncbi.nlm.nih.gov/33588751Actively Recruiting
Phase 4
Age: 18Years +
All Genders
Healthy Volunteers
ID07123870
Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns
Led by Kocaeli City Hospital · Updated on 2025-08-14
210
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how different anesthesia methods affect recovery after long spinal surgeries lasting more than three hours. The study compares total intravenous anesthesia (TIVA) alone with TIVA combined with low doses of either sevoflurane or desflurane inhaled anesthetics. The goal is to understand how these anesthesia approaches influence recovery times, including waking up, removing breathing tubes, agitation, nausea, vomiting, and discharge from recovery units. The study groups include three anesthesia methods: TIVA alone using a combination of propofol and remifentanil guided by BIS monitoring and target-controlled infusion, TIVA combined with 0.5 MAC sevoflurane, and TIVA combined with 0.5 MAC desflurane. Each participant receives one of these methods during their elective spinal surgery, all performed in a neurosurgery operating room. Participants will be monitored for recovery patterns such as time to eye opening after anesthesia, extubation time, agitation scores, incidence of nausea and vomiting, and time to discharge from the post-anesthesia care unit. These measures will be recorded within the first postoperative hour and beyond. The study follows participants through surgery and recovery to compare these outcomes across the anesthesia methods.
CONDITIONS
Brief Title
Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Scheduled for spine surgery
- Surgery expected to last longer than 3 hours
- Use of intraoperative neuromonitoring
- BIS-guided anesthesia administered
- TIVA with target-controlled infusion as primary anesthetic
- Age greater than 18 years
You will not qualify if you...
- Emergency surgeries
- Receiving only inhaled anesthesia without TIVA
- Perioperative dural injury
- Severe intraoperative hypotension requiring inotropic support
- Hypothermia before recovery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - Duration of the surgery (longer than 3 hours)
Participants receive one of three anesthesia methods during spinal surgery lasting longer than three hours, including combined intravenous-inhalational anesthesia or total intravenous anesthesia guided by BIS monitoring.
1 surgery visit (in-person)
Post-operative Follow-up
Duration - First postoperative hour
Participants are monitored for recovery parameters such as extubation time, eye opening, sedation levels, agitation incidence, nausea, vomiting, and time to discharge from the post-anesthesia care unit.
1 post-operative visit (in-person)
Trial Site Locations
Total: 1 location
1
Kocaeli City Hospital
Kocaeli, Izmıt, Turkey (Türkiye), Yozgat
Actively Recruiting
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Research Team
A
Ahmet YUKSEK, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Published Research Related To This Trial
Comparison of combined intravenous and inhalation anesthesia and total intravenous anesthesia in laparoscopic surgery and the identification of predictive factors influencing the delayed recovery of neurocognitive function.
Teng Song, Li-Jun Wu, Li Li
https://pubmed.ncbi.nlm.nih.gov/38590312Effect of combined intravenous-inhalation anesthesia on postoperative cognitive dysfunction after laparoscopic radical resection of cervical cancer: A protocol for systematic review and meta-analysis.
Ying Wang, Meihua Cao, Guofen Cao...
https://pubmed.ncbi.nlm.nih.gov/33157991