Actively Recruiting
Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis
Led by Tanta University · Updated on 2025-08-14
120
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults. Allergic rhinitis is a condition that causes sneezing, nasal congestion, and itchy or watery eyes. The main questions this study aims to answer are: • Do these supplements improve the quality of life for people with AR? Researchers will compare four groups: * People taking probiotics and vitamin D * People receiving standard treatment only (control group) Participants will: * Take a probiotic capsule daily and/or a vitamin D tablet (based on blood levels) for 12 weeks * Continue standard allergic rhinitis treatment (like antihistamines or nasal sprays) * Visit the clinic for checkups and lab tests * Complete surveys about their symptoms and quality of life This study will help researchers understand if adding probiotics and/or vitamin D to standard care can help people with allergic rhinitis feel better.
CONDITIONS
Official Title
Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of allergic rhinitis based on clinical history and specific IgE testing or screening by modified Mini Rhino-conjunctivitis Quality of Life Questionnaire
- Persistent rhinitis symptoms for at least two consecutive years
- Presence of two or more allergic rhinitis symptom domains such as sneezing, watery rhinorrhea, nasal itching, and nasal congestion lasting more than 1 hour daily without medication
- Symptoms may include eye itching, tearing, and redness
- Signed written informed consent and ability to complete the study as required
- Vitamin D insufficiency or deficiency (deficiency: < 20 ng/mL; insufficiency: 20-29 ng/mL)
You will not qualify if you...
- Use of systemic corticosteroids, immunosuppressive therapy, or medications affecting gut microbiota within 4 weeks before screening
- Regular use of probiotics, prebiotics, or vitamin D supplements within 6 months before screening
- Use of medications or supplements that alter serum 25(OH)D levels (e.g., barbiturates, bisphosphonates, anticonvulsants) prior to screening
- Diagnosed with pulmonary tuberculosis, allergic asthma, COPD, mast cell activation syndrome, or other respiratory diseases needing treatment
- Coexisting nasal polyps, severe nasal septum deviation, severe gastrointestinal diseases, metabolic syndrome, chronic systemic diseases, or malignancies
- History of autoimmune diseases or chronic inflammatory conditions
- Sinusitis, otitis media, or respiratory infections within 14 days before study start
- Known allergy or hypersensitivity to probiotics or other study interventions
- Signs or symptoms of kidney, liver, or heart disease
- Pregnant or lactating women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta University Hospital, ENT Department
Tanta, Gharbia Governorate, Egypt
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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