Actively Recruiting
Effect of the Consumption of Milk With Beta-casein A2A2, Milk With Beta-casein A1A2 and a Plant-based Drink on Metabolic Health in Adults: IMPA-CT Study
Led by Dawid Madej · Updated on 2026-02-27
150
Participants Needed
1
Research Sites
32 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study was to identify and compare the effects of daily consumption of A2 milk, conventional milk, and an oat drink on bone health, cardiometabolic health, and immune system function in adults. Although cow's milk plays an important role in human nutrition, its proteins-particularly β-caseins-exhibit significant genetic diversity. Conventional milk typically contains a mix of A1 and A2 β-casein variants, whereas A2 milk contains exclusively the A2/A2 variant. The key difference between the two lies in a single amino acid at position 67: variant A1 contains histidine, which allows digestive enzymes to release the opioid peptide β-casomorphin-7 (BCM-7), while variant A2 contains proline, which prevents the release of this peptide. Consequently, the study is trying to answer the question of whether 12 weeks of consuming 500 ml of A2 milk daily-thereby eliminating dietary exposure to BCM-7-results in different outcomes for bone health (the primary measure), as well as for cardiometabolic health and immune function, when compared to consuming conventional milk or a plant-based oat drink in healthy adults aged 30-60.
CONDITIONS
Official Title
Effect of the Consumption of Milk With Beta-casein A2A2, Milk With Beta-casein A1A2 and a Plant-based Drink on Metabolic Health in Adults: IMPA-CT Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 30 to 60 years
- Body mass index between 18.5 and 30 kg/m2
- No diagnosed chronic disease such as diabetes, cancer, or kidney disease
- Not taking medications or dietary supplements that affect carbohydrate or lipid metabolism
You will not qualify if you...
- Pregnancy or lactation in women
- Implanted medical materials like pacemaker, defibrillator, stent, or metal sutures in heart or blood vessels
- Previous radiotherapy or chemotherapy
- Significantly modified diet such as ketogenic, vegetarian, or ovo-vegetarian, or health condition requiring a specialist diet
- Unable to give informed consent
- Unable or unwilling to comply with study procedures
- History of gastrointestinal surgery or disorders including inflammatory bowel disease, ulcerative colitis, coeliac disease, or Crohn's disease
- Cardiorespiratory problems
- Uncontrolled diabetes mellitus
- Bleeding disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Warsaw Univeristy of Life Science
Warsaw, Masovian Voivodeship, Poland, 02-776
Actively Recruiting
Research Team
J
Jadwiga Hamulka Prof. dr hab., Prof. dr hab.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here