Actively Recruiting
Led by Philipp Schuetz · Updated on 2024-11-20
1200
Participants Needed
18
Research Sites
N/A
Total Duration
Researchers are evaluating the effect of continued nutritional support after hospital discharge compared to usual care in medical patients at nutritional risk. This trial focuses on adults who have experienced malnutrition, a condition linked to higher risks of death, rehospitalization, and loss of function, especially among elderly and multi-ill patients. Previous studies showed that in-hospital nutritional support helps reduce complications and mortality, but the long-term benefits after discharge remain unclear. Participants are randomly assigned to one of two groups. The intervention group receives customized nutritional support from an experienced dietician to meet their individual energy and protein needs, including oral nutritional supplements as needed. The control group receives general advice on healthy eating habits at discharge without ongoing nutritional support. Follow-up includes regular phone calls every 2 to 4 weeks to monitor adherence and adjust dietary plans as necessary. During the study, participants are monitored for up to three years. Researchers assess key outcomes such as time to death from any cause, hospital readmissions, major complications, and changes in functional status using the Barthel index. Quality of life is measured with the European Quality of Life 5 Dimensions index and a visual-analogue scale at regular intervals by phone. This comprehensive follow-up helps determine whether sustained nutritional support after discharge improves long-term health and recovery.
CONDITIONS
Effect of Continued Nutritional Support at Hospital Discharge on Mortality, Frailty, Functional Outcomes and Recovery
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants receive either individualized nutritional support including oral nutritional supplements and regular dietician phone calls every 2 to 4 weeks, or general information on healthy food habits at discharge without nutritional support.
Phone calls every 2 to 4 weeks for nutritional support group; general information provided at discharge for control group
Duration - Up to 3 years
Participants are monitored for outcomes such as mortality, hospital readmission, functional status, and quality of life via phone calls every 6 months.
Phone calls every 6 months
Total: 18 locations
1
Hospital Universitari Vall Hebron de Barcelona
Barcelona, Spain
Actively Recruiting
2
Hospital Universitario de Getafe
Getafe, Spain
Actively Recruiting
3
Complejo AComplejo Asistencial Universitario de León
León, Spain
Actively Recruiting
4
Hospital U. Gregorio Marañón de Madrid
Madrid, Spain
Actively Recruiting
5
Hospital Universitario Regional de Málaga
Málaga, Spain
Actively Recruiting
6
Hospital Clínico Universitario de Valladolid
Valladolid, Spain
Actively Recruiting
7
Spital Zofingen
Zofingen, Canton of Aargau, Switzerland, 4800
Completed
8
Spital Emmental Burgdorf
Burgdorf, Canton of Bern, Switzerland, 3400
Completed
9
Spital Thun
Thun, Canton of Bern, Switzerland, 3600
Actively Recruiting
10
Spital Lachen
Lachen, Canton of Schwyz, Switzerland, 8853
Actively Recruiting
11
Kantonsspital Münsterlingen
Münsterlingen, Thurgau, Switzerland, 8596
Actively Recruiting
12
Kantonsspital Aarau, University Department of Internal Medicine
Aarau, Switzerland, 5001
Actively Recruiting
13
Bern University Hospital, Department of General Internal Medicine
Bern, Switzerland
Completed
14
Kantonsspital Lucerne, Department of Internal Medicine
Lucerne, Switzerland
Completed
15
Kantonsspital Sankt Gallen
Sankt Gallen, Switzerland, 9007
Completed
16
Klinik Hirslanden Zürich
Zurich, Switzerland, 8032
Completed
17
Stadtspital Zürich
Zurich, Switzerland, 8063
Completed
18
Universitätsspital Zürich
Zurich, Switzerland, 8091
Completed
P
Philipp Schuetz, Prof. Dr. med.
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Carla Wunderle, Pascal Tribolet, Nina Kaegi-Braun...
https://pubmed.ncbi.nlm.nih.gov/41857825