Continuous Intravenous Lidocaine Infusion to Reduce Lung Complications and Improve Outcomes After Emergency Surgery for Intra-abdominal Infection

What this Trial Is About

Researchers are evaluating the effect of a continuous 24-hour intravenous infusion of lidocaine on the occurrence of postoperative pulmonary complications PPCs in patients undergoing emergency laparotomy for intra-abdominal infection IAI. The study also aims to assess how this lidocaine infusion may influence the need for mechanical ventilation, protect key organ functions during surgery, reduce hospital stay length, and affect outcomes within 30 days after surgery. Participants are randomly assigned to one of two groups one receives a loading dose of lidocaine followed by a continuous infusion for 24 hours after surgery, while the other receives an equivalent volume of normal saline as a placebo. Both groups undergo the same anesthesia, pain control, lung-protective ventilation, and other supportive care strategies during the perioperative period. During the study, patients are closely monitored for signs of PPCs within 2 days after surgery, including atelectasis, unplanned ventilation, acute respiratory distress syndrome, and pneumonia. Researchers will also track mechanical ventilation needs, organ function protection, hospital stay duration, and health outcomes for up to 30 days postoperatively. The study involves various assessments such as imaging and blood tests to diagnose complications and evaluate recovery.

The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI