Actively Recruiting
The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI
Led by Shanghai Zhongshan Hospital · Updated on 2026-04-29
428
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
Sponsors
S
Shanghai Zhongshan Hospital
Lead Sponsor
T
The Affiliated Hospital of Xuzhou Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main purpose of this study is to evaluate the impact of continuous 24-hour intravenous infusion of lidocaine on the incidence of PPCs in patients undergoing emergency laparotomy for intra-abdominal infection (IAI).The secondary objectives of this study are to assess the impact of continuous 24-hour intravenous lidocaine infusion on the proportion of patients requiring mechanical ventilation, protection of important organ function during the perioperative period, length of hospital stay, and outcomes within 30 days postoperatively.
CONDITIONS
Official Title
The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years, any gender
- Patients suspected of digestive tract perforation or obstruction confirmed by imaging, requiring emergency surgery
- Planned use of general anesthesia for surgery
- Patient or family has read and signed informed consent
- Evidence of inflammation such as elevated serum procalcitonin, leukocytosis (>12×10^9/L), leukopenia (<4×10^9/L), or >10% naive leukocytes
You will not qualify if you...
- History of allergy to local anesthetic drugs
- Pregnant patients
- Receiving renal replacement therapy
- Having arrhythmias or heart failure (second or third-degree atrioventricular block or reduced left ventricular ejection fraction)
- Preoperative platelet count <80 × 10^9/L
- Need for secondary surgery due to postoperative anastomotic fistula
- Participation in other clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital,Fudan university
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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