Actively Recruiting
The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients
Led by Gelderse Vallei Hospital · Updated on 2026-03-13
124
Participants Needed
5
Research Sites
152 weeks
Total Duration
On this page
Sponsors
G
Gelderse Vallei Hospital
Lead Sponsor
Z
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients. The aim of this study is to: • To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition. Participants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.
CONDITIONS
Official Title
The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Receiving or eligible to receive exclusive gastric tube feeding
- Expected intensive care unit stay of at least 48 hours
- Receiving or expected to receive invasive mechanical ventilation within 48 hours after ICU admission
You will not qualify if you...
- Participation considered clinically unsafe by treating clinician (e.g., feeding regimen change, unable to place CGM on arms, unable to receive exclusive gastric tube feeding)
- Imminent or inevitable death during admission with no active treatment commitment
- Pregnancy
- Expected fasting for 12 hours or more during the study period due to medical procedures
- Readmission to ICU within the last 14 days
- Presence of burn injuries
- Participation in another nutritional intervention study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Gelderse Vallei Hospital
Ede, Gelderland, Netherlands, 6716 RP
Actively Recruiting
2
Deventer Ziekenhuis
Deventer, Overijssel, Netherlands, 7416 SE
Actively Recruiting
3
Medisch Spectrum Twente
Enschede, Overijssel, Netherlands, 7512KZ
Actively Recruiting
4
Martini Ziekenhuis
Groningen, Provincie Groningen, Netherlands, 9728NT
Actively Recruiting
5
Haga Ziekenhuis
The Hague, South Holland, Netherlands, 2545 AA
Actively Recruiting
Research Team
A
Arthur RH van Zanten
CONTACT
I
Imre WK Kouw
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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