Actively Recruiting
The Effect of Corticosteroids on Quality of Life Following Total Hip Arthroplasty: HIPSTER Study
Led by Ziekenhuis Oost-Limburg · Updated on 2026-04-08
224
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Total hip arthroplasty (THA) is a highly effective and commonly performed procedure for end-stage osteoarthritis. Perioperative inflammation contributes to postoperative pain, fatigue, and delayed recovery. Dexamethasone, a potent glucocorticoid with strong anti-inflammatory properties, is widely used in orthopedic surgery and incorporated into Enhanced Recovery After Surgery (ERAS) protocols for THA to reduce pain, PONV, and fatigue. While intermediate doses of dexamethasone (25 mg) are considered safe and beneficial in the short term, their long-term effects on health-related quality of life and persistent pain remain unclear. Therefore, the main objective of the HIPSTER trial is to evaluate the effect of different doses of a single intraoperative intravenous dose of dexamethasone (5 mg versus 25 mg) on health-related quality of life up to three months after surgery.
CONDITIONS
Official Title
The Effect of Corticosteroids on Quality of Life Following Total Hip Arthroplasty: HIPSTER Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- aged 60 years or older;
- scheduled for elective total hip arthroplasty;
- procedure under spinal anaesthesia.
You will not qualify if you...
- hip revision surgery (reoperation);
- bilateral total hip arthroplasty during the same procedure;
- known hypersensitivity to dexamethasone or other corticosteroids;
- chronic systemic use of corticosteroids, defined as daily corticosteroid therapy for > 4 weeks within the last 3 months, with anticipated need for a perioperative stress dose of corticosteroids;
- active gastric of intestinal ulcers;
- lack of informed consent or inability to give informed consent;
- urgent, non-elective surgery.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Ziekenhuis Oost-Limburg
Genk, Limburg, Belgium, 3600
Not Yet Recruiting
2
Ziekenhuis Oost-Limburg
Genk, Belgium
Actively Recruiting
Research Team
S
Steven Thiessen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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