Actively Recruiting
Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
Led by Ohio State University · Updated on 2025-08-13
227
Participants Needed
2
Research Sites
264 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
U
University of Pennsylvania
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.
CONDITIONS
Official Title
Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-75 years
- Moderate-severe obstructive sleep apnea (ODI 6510 events/hour) diagnosed by sleep study
- Excessively sleepy subtype based on patient-reported symptoms
- Willing to use CPAP therapy
- Elevated baseline blood pressure defined as 60120 or 6080 mmHg
- Planned positive airway pressure treatment (CPAP or bi-level PAP) by healthcare provider
You will not qualify if you...
- Recent changes to blood pressure medications within 3 months
- Unable to wear an ambulatory blood pressure monitoring cuff
- Current use of CPAP or other obstructive sleep apnea treatments
- Resting awake oxygen saturation below 90% or use of home oxygen
- New York Heart Association categories III-IV heart failure
- Presence of Cheyne-Stokes Respiration in sleep study
- Predominantly central sleep apnea (AHI 6515 events/hour with >50% central events)
- Life expectancy less than 2 years
- Pregnancy
- Chronic kidney disease stage 5 requiring dialysis or renal transplant
- Systolic blood pressure above 180 mmHg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600
Columbus, Ohio, United States, 43221
Actively Recruiting
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
A
Alicia Gonzalez Zacarias, MD
CONTACT
J
Joseph Santiago, RRT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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