Actively Recruiting
Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC
Led by Beth Israel Deaconess Medical Center · Updated on 2026-04-13
32
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this protocol is to perform a prospective, randomized, double-blinded, pacebo-controlled clinical trial to determine the influence of a non-invasive positive pressure ventilation device on exercise capacity and symptoms in adult patients with ECAC. Primary outcome will include the total distance traversed by the study subject during a standard 6-minute walk test, and secondary outcomes will include peak flow measurement and symptom reporting before and after the exercise testing. The study will focus on the use of continuous positive airway pressure (CPAP) device. CPAP is FDA-approved for the treatment of various medical conditions, including obstructive sleep apnea and heart failure, but is not FDA-approved for the treatment of ECAC. The study will enroll 32 ambulatory study subjects with confirmed ECAC at the BIDMC, and each study subject will be monitored for up to 3 months.
CONDITIONS
Official Title
Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ECAC confirmed by bronchoscopy or CT scan
- Age over 18 years
- Scheduled for diagnostic or therapeutic bronchoscopy as part of standard care
- Have a baseline 6-minute walk test
- No prior use of CPAP devices
You will not qualify if you...
- Poorly controlled respiratory conditions such as asthma, COPD, obstructive sleep apnea, GERD, or relapsing polychondritis
- Acute respiratory tract infection or infection within the past 3 weeks
- Resting bradycardia below 50 beats per minute, frequent multifocal premature ventricular contractions, complex ventricular arrhythmia, or sustained supraventricular tachycardia
- Any dysrhythmia posing risk during exercise or training
- Any condition interfering with completion of assessments
- Comorbidities significantly limiting exercise capacity (e.g., severe arthritis, planned knee surgery) or non-dyspnea related baseline limitations
- Unable to walk more than 140 meters in 6 minutes
- Unable to tolerate bronchoscopy under sedation or anesthesia
- Known sensitivity to drugs used during bronchoscopy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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