Daily Gazpacho Intake with Mediterranean Diet to Improve Semen Quality in Men Aged 18 to 45 with Altered Semen Parameters

What this Trial Is About

Researchers are studying whether drinking a daily serving of gazpacho can improve semen quality in men with altered sperm parameters such as oligozoospermia, asthenozoospermia, or teratozoospermia. The study also aims to understand if this dietary change affects oxidative stress levels in semen and whether daily gazpacho intake is well tolerated as part of a Mediterranean diet. This is a randomized, open-label study conducted at a single center focusing on male infertility and related conditions. Participants will be randomly assigned to one of two groups one group will follow a standardized Mediterranean diet for 12 weeks, and the other group will follow the same diet plus consume 330 mL of commercially available gazpacho daily with a main meal. The study will analyze nutrient content in the gazpacho and monitor adherence through diaries and phone calls. The intervention period lasts 12 weeks, after which semen samples will be collected and analyzed. During the study, participants will provide semen samples at the start and after 12 weeks to assess changes in semen volume, sperm concentration, motility, and morphology following WHO 2021 guidelines. Oxidative stress in semen will also be measured using a specialized test. Participants will keep a diary to track adherence and will be followed for up to 18 months to record reproductive outcomes such as pregnancy and live birth rates. Safety, tolerability, and treatment adherence will be monitored throughout the study duration.

Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress