Actively Recruiting
Effect of Daily Mixed Spice Consumption on Memory Function
Led by University of California, Los Angeles · Updated on 2025-03-21
50
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive abilities. The hypothesis is that a mixture of spices, acknowledged for their reported memory protection potential, may yield a more potent beneficial effect on memory function than a single spice. The spice mixture will be used at culinary dose, and therefore side effects are anticipated. In this study, the effects of spice mixture will be evaluated, as well as their anti-oxidant, and anti-inflammatory properties. The proposed pilot study will include 50 adults (ages 50-80), exhibiting typical age-related mild cognitive decline, excluding dementia or major neurocognitive disorders. They will be randomized 1:1 assigned into a daily intake of either 4.00 g spice mixture capsules or 4.00 g maltodextrin capsules over 3 months, and explore the sustainable effect over 3 additional months. The changes in symptoms of cognition, fatigue, and mood symptoms of the spice group vs. placebo group will be compared. The outcome of the investigation of the effects of mixed spice consumption will provide important novel information on dietary recommendation of spice to preserve cognitive function in aging population.
CONDITIONS
Official Title
Effect of Daily Mixed Spice Consumption on Memory Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have clinical histories consistent with normal aging or mild cognitive impairment (MCI).
- Age between 50 and 80 years.
- Adequate visual acuity and hearing to complete neuropsychological testing.
- Screening laboratory tests must not show significant abnormalities that could interfere with the study.
You will not qualify if you...
- Diagnosis of probable Alzheimer's disease or any other dementia (vascular, Lewy body, frontotemporal).
- Presence of other neurological or physical illnesses causing cognitive deterioration.
- Evidence of Parkinson's disease based on motor examination.
- Uncontrolled hypertension with systolic BP > 170 or diastolic BP > 100.
- Regular consumption of spices exceeding 5 grams per day.
- Allergy or sensitivity to spices or history of any allergy or anaphylaxis.
- Current diagnosis of major psychiatric disorder according to DSM-IV TR criteria.
- Current diagnosis of alcoholism or substance addiction.
- Eating a high fiber/polyphenol diet or using medications or supplements interfering with polyphenol absorption.
- Frequent use of prebiotics, probiotics, yogurt, or fiber supplements.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA Center for Human Nutrition
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
H
Hila Zelicha, RD PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
NA
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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