Effect of a Daily Nitric Oxide-Stimulating Supplement on Plasma PAI-1 Levels: a Six-Week, Open-Label Clinical Trial

What this Trial Is About

Researchers are investigating the effects of a natural oral supplement on blood markers linked to vascular aging and inflammation in healthy adults. The study focuses on understanding how the supplement influences Plasminogen Activator Inhibitor-1 (PAI-1) and other proteins connected to cardiovascular risk and aging. This research aims to explore potential ways to support vascular health by enhancing nitric oxide production, which is important for blood vessel function and preventing clotting. Participants will take the oral supplement, which contains ginger extract, L-citrulline, Paullinia cupana, and muira puama, twice daily for six weeks. The study is open-label, meaning all enrolled participants receive the supplement without a comparison group or placebo. The trial will measure changes in several blood markers such as PAI-1, Interleukin-8, PCSK9, FGF-23, C-Reactive Protein, and Klotho, which are associated with inflammation, cardiovascular health, and aging. During the study, participants will have blood samples taken to assess these markers at the beginning and at the end of the six-week supplementation period. Blood pressure will also be monitored. Researchers will evaluate the change in these markers to understand how the supplement may affect vascular aging and inflammation. The total participation time covers the six weeks of supplement intake with assessments at baseline and treatment end.

Effect of a Daily Supplement on Plasma PAI-1 Levels