Actively Recruiting
Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease: A Randomized Controlled Trial
Led by University of Alabama at Birmingham · Updated on 2026-01-13
48
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how a healthy diet might affect risk factors for kidney stone disease (KSD). This trial compares the effects of a Dietary Approaches to Stop Hypertension (DASH)-style diet versus a Western-style diet on urinary stone risk parameters. The goal is to understand if the DASH diet can improve measures related to kidney stones and to create a foundation for future dietary studies in this area. Participants will be randomly assigned to one of two diet groups for one week. One group will follow a DASH-style diet rich in fruits, vegetables, low-fat dairy, whole grains, poultry, fish, and nuts, while limiting red meat, sweets, and sugary drinks. The other group will follow a Western-style diet with higher amounts of red meat, sweets, processed starches, and seed oils, and lower intake of fruits, vegetables, and low-fat dairy. All meals will be provided by the Bionutrition Unit. During the study, participants will complete 24-hour urine collections to measure key urinary factors related to kidney stone risk, including calcium oxalate supersaturation. Researchers will compare these outcomes between the two diet groups on days 6 and 7 of the diet period. The study includes monitoring safety and adherence, and participants will be involved for the duration of the one-week diet intervention.
CONDITIONS
Brief Title
Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants of the CARDIA study in Birmingham, AL or patients of University of Alabama at Birmingham/Kirklin Clinic
- Self-reported, documented, or imaging-confirmed diagnosis of kidney stone disease
- Age between 19 and 89 years
- Any sex and any race
- Able to provide informed consent
- Willing to perform 24-hour urine collections
- Willing to consume meals prepared by the study's Bionutrition Unit
- No known food allergies or intolerance to study foods
- Willing to stop multivitamins and dietary supplements (including calcium and vitamin C) for 7 days before and during the study
You will not qualify if you...
- Currently on dialysis
- Kidney transplant recipient
- Estimated glomerular filtration rate below 60 ml/min/1.73m2
- Renal tubular acidosis
- Using acetazolamide, topiramate, or zonisamide
- Primary hyperparathyroidism or history of parathyroid surgery
- Hyperthyroidism
- Sarcoidosis
- Primary hyperoxaluria
- Cystinuria
- Nephrotic syndrome
- Malabsorptive conditions like inflammatory bowel disease or history of surgeries such as Roux-en-Y gastric bypass
- Urinary retention requiring catheterization
- Urinary diversion
- Pregnant or breastfeeding
- Cancer treated within the past 12 months except non-melanoma skin cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days
Participants consume either a DASH-style diet or a Western-style diet for seven days to assess urinary risk factors for kidney stone disease.
Daily visits or check-ins during the 7-day diet period
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
J
Joseph Crivelli, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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